Synonym
Chlorin e6 monolysine amide (3Na); Chlorin e6 monolysine amide (Trisodium salt);
IUPAC/Chemical Name
sodium (7S,8S)-5-(2-((5-amino-1-carboxylatopentyl)amino)-2-oxoethyl)-7-(2-carboxylatoethyl)-18-ethyl-2,8,12,17-tetramethyl-13-vinyl-7H,8H-porphyrin-3-carboxylate
InChi Key
KBEDDHWRHNPUGA-IPRSSYSWSA-K
InChi Code
InChI=1S/C40H48N6O7.3Na/c1-7-23-19(3)28-16-30-21(5)25(12-13-35(48)49)37(45-30)26(15-34(47)44-27(39(50)51)11-9-10-14-41)38-36(40(52)53)22(6)31(46-38)18-33-24(8-2)20(4)29(43-33)17-32(23)42-28;;;/h7,16-18,21,25,27,42,46H,1,8-15,41H2,2-6H3,(H,44,47)(H,48,49)(H,50,51)(H,52,53);;;/q;3*+1/p-3/b28-16-,29-17-,30-16-,31-18-,32-17-,33-18-,37-26-,38-26-;;;/t21-,25-,27?;;;/m0.../s1
SMILES Code
NCCCCC(C(O[Na])=O)NC(C/C(C1=C(C(O[Na])=O)C(C)=C(N1)/C=C(N=C2/C=C3\N4)/C(CC)=C2C)=C5[C@@H](CCC(O[Na])=O)[C@H](C)C(/C=C4/C(C)=C3C=C)=N\5)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
790.80
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1.) Hädener, et al. Interactions of Polyvinylpyrrolidone with Chlorin e6-Based Photosensitizers Studied by NMR and Electronic Absorption Spectroscopy. J. Phys. Chem. B 2015, 119, 36, 12117–12128. https://doi.org/10.1021/acs.jpcb.5b05761
2.) Gjuroski, et al. How Does the Encapsulation of Porphyrinic Photosensitizers into Polymer Matrices Affect Their Self-Association and Dynamic Properties? ChemPhysChem.Volume 19, Issue 9, May 7, 2018, Pages 1089-1102. https://doi.org/10.1002/cphc.201701318
3.) Sang, et al. A Triple-Kill Strategy for Tumor Eradication Reinforced by Metal-Phenolic Network Nanopumps. AdvancedFunctionalMaterials. Volume 32, Issue 21, May 19, 2022, 2113168. https://doi.org/10.1002/adfm.202113168
4.) Sang, et al. Oxygen-Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy. Advanced Science. Volume 8, Issue 4, February 17, 2021, 2003338. https://doi.org/10.1002/advs.202003338
