Synonym
GLN00709; GLN 00709; GLN-00709; Chlorin e6 mono 6-amino hexanoic acid amide;
IUPAC/Chemical Name
(7S,8S)-7-(2-carboxyethyl)-5-(2-((5-carboxypentyl)amino)-2-oxoethyl)-18-ethyl-2,8,12,17-tetramethyl-13-vinyl-7H,8H-porphyrin-3-carboxylic acid
InChi Key
GGRVPWFNRZEHGG-LVPXDCJOSA-N
InChi Code
InChI=1S/C40H47N5O7/c1-7-24-20(3)28-17-30-22(5)26(13-14-36(49)50)38(44-30)27(16-34(46)41-15-11-9-10-12-35(47)48)39-37(40(51)52)23(6)31(45-39)19-33-25(8-2)21(4)29(43-33)18-32(24)42-28/h7,17-19,22,26,42,45H,1,8-16H2,2-6H3,(H,41,46)(H,47,48)(H,49,50)(H,51,52)/b28-17-,29-18-,30-17-,31-19-,32-18-,33-19-,38-27-,39-27-/t22-,26-/m0/s1
SMILES Code
CC1=C(/C2=C/C3=C(C(C(O)=O)=C(N3)/C(CC(NCCCCCC(O)=O)=O)=C4[C@H]([C@@H](C(/C=C(C(C)=C/5C=C)\NC5=C/C1=N2)=N/4)C)CCC(O)=O)C)CC
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
709.84
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1.) Hadener, et al. Interactions of Polyvinylpyrrolidone with Chlorin e6-Based Photosensitizers Studied by NMR and Electronic Absorption Spectroscopy. Journal of Physical Chemistry B, 2015, vol. 119, # 36, p. 12117 – 12128. https://doi.org/10.1021/acs.jpcb.5b05761
2.) Yan, et al. All-natural-molecule, bioluminescent photodynamic therapy results in complete tumor regression and prevents metastasis. Biomaterials, Volume 296, May 2023, 122079. https://doi.org/10.1016/j.biomaterials.2023.122079
3.) Vermathen, et al. Self-Assembling Properties of Porphyrinic Photosensitizers and Their Effect on Membrane Interactions Probed by NMR Spectroscopy. J. Phys. Chem. B 2013, 117, 23, 6990–7001. https://doi.org/10.1021/jp403331n
4.) Gjuroski, et al. Probing the Interactions of Porphyrins with Macromolecules Using NMR Spectroscopy Techniques. Molecules 2021, 26(7), 1942; https://doi.org/10.3390/molecules26071942
