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MedKoo Cat#: 145372 | Name: NUDOL

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NUDOL is a phenanthrene compound from the traditional Chinese medicine, Dendrobium nobile. NUDOL exhibits antiproliferative activity against osteosarcoma cells. Nudol might have the potential for further development as a lead compound against bone tumor.

Chemical Structure

NUDOL
NUDOL
CAS#86630-46-8

Theoretical Analysis

MedKoo Cat#: 145372

Name: NUDOL

CAS#: 86630-46-8

Chemical Formula: C16H14O4

Exact Mass: 270.0892

Molecular Weight: 270.28

Elemental Analysis: C, 71.10; H, 5.22; O, 23.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
NUDOL;
IUPAC/Chemical Name
3,4-dimethoxyphenanthrene-2,7-diol
InChi Key
JZIYNZGPIKGKQC-UHFFFAOYSA-N
InChi Code
1S/C16H14O4/c1-19-15-13(18)8-10-4-3-9-7-11(17)5-6-12(9)14(10)16(15)20-2/h3-8,17-18H,1-2H3
SMILES Code
COC1=C(OC)C2=C3C=CC(O)=CC3=CC=C2C=C1O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 270.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang Y, Zhang Q, Xin W, Liu N, Zhang H. Nudol, a phenanthrene derivative from Dendrobium nobile, induces cell cycle arrest and apoptosis and inhibits migration in osteosarcoma cells. Drug Des Devel Ther. 2019 Jul 29;13:2591-2601. doi: 10.2147/DDDT.S180610. PMID: 31551653; PMCID: PMC6677380. 2: Ma XJ, Cui BS, Han SW, Li S. [Chemical constituents from tuber of Bletilla striata]. Zhongguo Zhong Yao Za Zhi. 2017 Apr;42(8):1578-1584. Chinese. doi: 10.19540/j.cnki.cjcmm.2017.0051. PMID: 29071865. 3: Wu YP, Liu WJ, Zhong WJ, Chen YJ, Chen DN, He F, Jiang L. Phenolic compounds from the stems of Flickingeria fimbriata. Nat Prod Res. 2017 Jul;31(13):1518-1522. doi: 10.1080/14786419.2017.1278599. Epub 2017 Feb 21. PMID: 28278646. 4: Estrada S, López-Guerrero JJ, Villalobos-Molina R, Mata R. Spasmolytic stilbenoids from Maxillaria densa. Fitoterapia. 2004 Dec;75(7-8):690-5. doi: 10.1016/j.fitote.2004.08.004. PMID: 15567245. 5: Réthy B, Kovács A, Zupkó I, Forgo P, Vasas A, Falkay G, Hohmann J. Cytotoxic phenanthrenes from the rhizomes of Tamus communis. Planta Med. 2006 Jun;72(8):767-70. doi: 10.1055/s-2006-941505. Epub 2006 Jun 19. PMID: 16783700. 6: Li RS, Yang X, He P, Gan N. [Studies on phenanthrene constituents from stems of Dendrobium candidum]. Zhong Yao Cai. 2009 Feb;32(2):220-3. Chinese. PMID: 19504966. 7: Ehounou AE, Cormier F, Maledon E, Nudol E, Vignes H, Gravillon MC, N'guetta ASP, Mournet P, Chaïr H, Kouakou AM, Arnau G. Identification and validation of QTLs for tuber quality related traits in greater yam (Dioscorea alata L.). Sci Rep. 2022 May 19;12(1):8423. doi: 10.1038/s41598-022-12135-2. PMID: 35589821; PMCID: PMC9120205. 8: Cormier F, Lawac F, Maledon E, Gravillon MC, Nudol E, Mournet P, Vignes H, Chaïr H, Arnau G. A reference high-density genetic map of greater yam (Dioscorea alata L.). Theor Appl Genet. 2019 Jun;132(6):1733-1744. doi: 10.1007/s00122-019-03311-6. Epub 2019 Feb 20. PMID: 30783744; PMCID: PMC6531416. 9: Arnau G, Desfontaines L, Ehounou AE, Marie-Magdeleine C, Kouakou AM, Leinster J, Nudol E, Maledon E, Chair H. Quantitative trait loci and candidate genes for physico-chemical traits related to tuber quality in greater yam (Dioscorea alata L.). J Sci Food Agric. 2024 Jun;104(8):4872-4879. doi: 10.1002/jsfa.12822. Epub 2023 Jul 29. PMID: 37400964. 10: Nemorin A, David J, Maledon E, Nudol E, Dalon J, Arnau G. Microsatellite and flow cytometry analysis to help understand the origin of Dioscorea alata polyploids. Ann Bot. 2013 Sep;112(5):811-9. doi: 10.1093/aob/mct145. Epub 2013 Aug 1. PMID: 23912697; PMCID: PMC3747798.