IUPAC/Chemical Name
(1aR,2R,5R,6R,6aS)-5-hexyl-2,6-dihydroxy-2,5,6,6a-tetrahydrooxireno[2,3-f]isobenzofuran-3(1aH)-one
InChi Key
OHAVJEXAZZCXML-KDRYVUTISA-N
InChi Code
1S/C14H20O5/c1-2-3-4-5-6-7-8-9(14(17)18-7)11(16)13-12(19-13)10(8)15/h7,10-13,15-16H,2-6H2,1H3/t7-,10-,11-,12+,13-/m1/s1
SMILES Code
CCCCCC[C@H]1OC(=O)C2=C1[C@@H](O)[C@@H]3O[C@@H]3[C@@H]2O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
268.31
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Miura S, Ishida K, Tanaka K, Morita E, Hashimoto M. Integrasone Derivatives Isolated from Lepteutypa sp. KT4162 and Their Anti-HIV-1 Integrase Activity. J Nat Prod. 2023 Apr 28;86(4):1019-1024. doi: 10.1021/acs.jnatprod.3c00065. Epub 2023 Mar 10. PMID: 36898139.
2: Mehta G, Roy S. Enantioselective total synthesis of a novel polyketide natural product (+)-integrasone, an HIV-1 integrase inhibitor. Chem Commun (Camb). 2005 Jul 7;(25):3210-2. doi: 10.1039/b502024g. Epub 2005 May 24. PMID: 15968374.
3: Herath KB, Jayasuriya H, Bills GF, Polishook JD, Dombrowski AW, Guan Z, Felock PJ, Hazuda DJ, Singh SB. Isolation, structure, absolute stereochemistry, and HIV-1 integrase inhibitory activity of integrasone, a novel fungal polyketide. J Nat Prod. 2004 May;67(5):872-4. doi: 10.1021/np0340504. PMID: 15165153.
4: Almeida C, Ortega H, Higginbotham S, Spadafora C, Arnold AE, Coley PD, Kursar TA, Gerwick WH, Cubilla-Rios L. Chemical and bioactive natural products from Microthyriaceae sp., an endophytic fungus from a tropical grass. Lett Appl Microbiol. 2014 Jul;59(1):58-64. doi: 10.1111/lam.12245. Epub 2014 Mar 28. PMID: 24612068.
