Propyphenazone | CAS#479-92-5 | Pyrazolone Derivative

MedKoo Cat#: 150134 | Name: Propyphenazone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity. It was introduced for the treatment of different types of pain and fever and rheumatic disorders. Propyphenazone structurally relates to aminophenazone it has been associated with severe blood dyscrasias.

Chemical Structure

Propyphenazone

CAS#479-92-5

Theoretical Analysis

MedKoo Cat#: 150134

Name: Propyphenazone

CAS#: 479-92-5

Chemical Formula: C14H18N2O

Exact Mass: 230.1420

Molecular Weight: 230.31

Elemental Analysis: C, 73.01; H, 7.88; N, 12.16; O, 6.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Isopropyl Phenazone; Propyphenazone; isopropylantipyrine; 4-Isopropylantipyrine;

IUPAC/Chemical Name

1,5-dimethyl-2-phenyl-4-propan-2-ylpyrazol-3-one

InChi Key

PXWLVJLKJGVOKE-UHFFFAOYSA-N

InChi Code

1S/C14H18N2O/c1-10(2)13-11(3)15(4)16(14(13)17)12-8-6-5-7-9-12/h5-10H,1-4H3

SMILES Code

O=C1N(C2=CC=CC=C2)N(C)C(C)=C1C(C)C

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 230.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Radwan MF, Dalby KN, Kaoud TS. Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors. ACS Med Chem Lett. 2014 Jun 23;5(9):983-8. doi: 10.1021/ml500156v. PMID: 25221653; PMCID: PMC4160749. 2: Yegles M, Wenning R. Incorporation of propyphenazone in beard hair of a migraine patient. Forensic Sci Int. 2000 Jan 10;107(1-3):233-7. doi: 10.1016/s0379-0738(99)00174-7. PMID: 10689575. 3: Volz M, Kellner HM. Kinetics and metabolism of pyrazolones (propyphenazone, aminopyrine and dipyrone). Br J Clin Pharmacol. 1980 Oct;10 Suppl 2(Suppl 2):299S-308S. doi: 10.1111/j.1365-2125.1980.tb01813.x. PMID: 7002187; PMCID: PMC1430198. 4: Brogden RN. Pyrazolone derivatives. Drugs. 1986;32 Suppl 4:60-70. doi: 10.2165/00003495-198600324-00006. PMID: 3552586.