MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 145313 | Name: Tiafenacil
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tiafenacil is a newly registered herbicide and a protoporphyrinogen IX oxidase inhibitor. Tiafenacil is a new protoporphyrinogen IX oxidase (PPO)-inhibiting pyrimidinedione herbicide. Tiafenacil is non-selective and is herbicidal to both dicots and monocots.

Chemical Structure

Tiafenacil
Tiafenacil
CAS#1220411-29-9

Theoretical Analysis

MedKoo Cat#: 145313

Name: Tiafenacil

CAS#: 1220411-29-9

Chemical Formula: C19H18ClF4N3O5S

Exact Mass: 511.0592

Molecular Weight: 511.87

Elemental Analysis: C, 44.58; H, 3.54; Cl, 6.93; F, 14.85; N, 8.21; O, 15.63; S, 6.26

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
25mg USD 1,250.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Tiafenacil;
IUPAC/Chemical Name
methyl 3-(2-((2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl)phenyl)thio)propanamido)propanoate
InChi Key
QPTPZPIXUPELRM-UHFFFAOYSA-N
InChi Code
1S/C19H18ClF4N3O5S/c1-9(17(30)25-5-4-16(29)32-3)33-13-7-12(11(21)6-10(13)20)27-15(28)8-14(19(22,23)24)26(2)18(27)31/h6-9H,4-5H2,1-3H3,(H,25,30)
SMILES Code
COC(=O)CCNC(=O)C(C)SC1=C(Cl)C=C(F)C(=C1)N2C(=O)C=C(N(C)C2=O)C(F)(F)F
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 511.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ivantsova E, Konig I, Lopez-Scarim V, English C, Charnas SR, Souders CL, Martyniuk CJ. Molecular and behavioral toxicity assessment of tiafenacil, a novel PPO-inhibiting herbicide, in zebrafish embryos/larvae. Environ Toxicol Pharmacol. 2023 Mar;98:104084. doi: 10.1016/j.etap.2023.104084. Epub 2023 Feb 23. PMID: 36828158. 2: Gao M, Bian C, Zhou W, Liu L, Li B, Tang L. Dissipation of tiafenacil in five types of citrus orchard soils using the HPLC-MS coupled with the quick, easy, cheap, effective, rugged, and safe method. J Sep Sci. 2021 May;44(9):1950-1960. doi: 10.1002/jssc.202001128. Epub 2021 Mar 8. PMID: 33566428. 3: Hu M, Tan H, Li Y, Qiu J, Liu L, Zeng D. Simultaneous determination of tiafenacil and its six metabolites in fruits using ultra-high-performance liquid chromatography/tandem mass spectrometry. Food Chem. 2020 Oct 15;327:127015. doi: 10.1016/j.foodchem.2020.127015. Epub 2020 May 11. PMID: 32434124. 4: Park J, Ahn YO, Nam JW, Hong MK, Song N, Kim T, Yu GH, Sung SK. Biochemical and physiological mode of action of tiafenacil, a new protoporphyrinogen IX oxidase-inhibiting herbicide. Pestic Biochem Physiol. 2018 Nov;152:38-44. doi: 10.1016/j.pestbp.2018.08.010. Epub 2018 Aug 24. PMID: 30497709. 5: Mattison RL, Beffa R, Bojack G, Bollenbach-Wahl B, Dörnbrack C, Dorn N, Freigang J, Gatzweiler E, Getachew R, Hartfiel C, Heinemann I, Helmke H, Hohmann S, Jakobi H, Lange G, Lümmen P, Willms L, Frackenpohl J. Design, synthesis and screening of herbicidal activity for new phenyl pyrazole-based protoporphyrinogen oxidase-inhibitors (PPO) overcoming resistance issues. Pest Manag Sci. 2023 Jun;79(6):2264-2280. doi: 10.1002/ps.7425. Epub 2023 Mar 8. PMID: 36815643. 6: Yoon J, Han Y, Ahn YO, Hong MK, Sung SK. Characterization of HemY-type protoporphyrinogen IX oxidase genes from cyanobacteria and their functioning in transgenic Arabidopsis. Plant Mol Biol. 2019 Dec;101(6):561-574. doi: 10.1007/s11103-019-00925-8. Epub 2019 Oct 16. PMID: 31621006. 7: Alnafta N, Beffa R, Bojack G, Bollenbach-Wahl B, Brant NZ, Dörnbrack C, Dorn N, Freigang J, Gatzweiler E, Getachew R, Hartfiel C, Heinemann I, Helmke H, Hohmann S, Jakobi H, Lange G, Lümmen P, Willms L, Frackenpohl J. Designing New Protoporphyrinogen Oxidase-Inhibitors Carrying Potential Side Chain Isosteres to Enhance Crop Safety and Spectrum of Activity. J Agric Food Chem. 2023 Nov 29;71(47):18270-18284. doi: 10.1021/acs.jafc.3c01420. Epub 2023 Jun 3. PMID: 37269295. 8: Jeong SM, Noh TK, Kim DS. Herbicide Bioassay Using a Multi-Well Plate and Plant Spectral Image Analysis. Sensors (Basel). 2024 Jan 31;24(3):919. doi: 10.3390/s24030919. PMID: 38339634; PMCID: PMC10856836.