Synonym
Fluocortin Butyl; Fluocortin butyl ester; Vaspit;
IUPAC/Chemical Name
butyl 2-[(6S,8S,9S,10R,11S,13S,14S,16R,17S)-6-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoacetate
InChi Key
XWTIDFOGTCVGQB-FHIVUSPVSA-N
InChi Code
1S/C26H35FO5/c1-5-6-9-32-24(31)23(30)21-14(2)10-17-16-12-19(27)18-11-15(28)7-8-25(18,3)22(16)20(29)13-26(17,21)4/h7-8,11,14,16-17,19-22,29H,5-6,9-10,12-13H2,1-4H3/t14-,16+,17+,19+,20+,21-,22-,25+,26+/m1/s1
SMILES Code
O=C(OCCCC)C([C@H]1[C@H](C)C[C@@]2([H])[C@]3([H])C[C@H](F)C4=CC(C=C[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C)=O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
446.56
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Arbesman C, Bernstein IL, Bierman CW, Bocles JS, Katz R, Lieberman PL, Mattucci K, Meltzer EO, Middleton E Jr, Noyes J, Pearlman DS, Pence HL, Slavin RG, Spector SL. Multi-center, double-blind, placebo-controlled trial of fluocortin butyl in perennial rhinitis. J Allergy Clin Immunol. 1983 Jun;71(6):597-603. doi: 10.1016/0091-6749(83)90442-6. PMID: 6343462.
2: Orgel HA, Meltzer EO, Bierman CW, Bronsky E, Connell JT, Lieberman PL, Nathan R, Pearlman DS, Pence HL, Slavin RG, et al. Intranasal fluocortin butyl in patients with perennial rhinitis: a 12-month efficacy and safety study including nasal biopsy. J Allergy Clin Immunol. 1991 Aug;88(2):257-64. doi: 10.1016/0091-6749(91)90336-m. PMID: 1880325.
3: Hartley TF, Lieberman PL, Meltzer EO, Noyes JN, Pearlman DS, Tinkelman DG. Efficacy and tolerance of fluocortin butyl administered twice daily in adult patients with perennial rhinitis. J Allergy Clin Immunol. 1985 Apr;75(4):501-7. doi: 10.1016/s0091-6749(85)80024-5. PMID: 3884690.
