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MedKoo Cat#: 145312 | Name: Pyraoxystrobin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pyraoxystrobin is an QoI fungicide. Pyraoxystrobin is a novel strobilurin fungicide that is widely used on many crops. Pyraoxystrobin (2 and 4μg/L) significantly alters the mRNA levels of genes related to the mitochondrial respiratory chain.

Chemical Structure

Pyraoxystrobin
Pyraoxystrobin
CAS#862588-11-2

Theoretical Analysis

MedKoo Cat#: 145312

Name: Pyraoxystrobin

CAS#: 862588-11-2

Chemical Formula: C22H21ClN2O4

Exact Mass: 412.1190

Molecular Weight: 412.87

Elemental Analysis: C, 64.00; H, 5.13; Cl, 8.59; N, 6.79; O, 15.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Pyraoxystrobin;
IUPAC/Chemical Name
methyl (E)-2-(2-(((3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-yl)oxy)methyl)phenyl)-3-methoxyacrylate
InChi Key
URXNNPCNKVAQRA-XMHGGMMESA-N
InChi Code
1S/C22H21ClN2O4/c1-25-21(12-20(24-25)15-8-10-17(23)11-9-15)29-13-16-6-4-5-7-18(16)19(14-27-2)22(26)28-3/h4-12,14H,13H2,1-3H3/b19-14+
SMILES Code
CO\C=C(\C(=O)OC)C1=C(COC2=CC(=NN2C)C3=CC=C(Cl)C=C3)C=CC=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 412.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wu W, Xu J, Dou Y, Yu J, Kong D, Zhou L. Bioaccumulation of Pyraoxystrobin and Its Predictive Evaluation in Zebrafish. Toxics. 2021 Dec 24;10(1):5. doi: 10.3390/toxics10010005. PMID: 35051047; PMCID: PMC8780168. 2: Peng Q, Zhao H, Zhao G, Gao X, Miao J, Liu X. Resistance assessment of pyraoxystrobin in Magnaporthe oryzae and the detection of a point mutation in cyt b that confers resistance. Pestic Biochem Physiol. 2022 Jan;180:105006. doi: 10.1016/j.pestbp.2021.105006. Epub 2021 Dec 9. PMID: 34955180. 3: Yang X, Liu H, Jia M, Wang J, Wu J, Song J, Liu Y. Evaluation of pyraoxystrobin bioconcentration in zebrafish (Danio rerio) using modified QuEChERS extraction. J Environ Sci Health B. 2020;55(5):477-483. doi: 10.1080/03601234.2020.1722558. Epub 2020 May 23. PMID: 32449480. 4: Yang T, Chen Y, Wang Z, Ye Q, Wang H. Fate characterization of bound residues of 14C-Pyraoxystrobin in soils. Chemosphere. 2021 Jan;263:128023. doi: 10.1016/j.chemosphere.2020.128023. Epub 2020 Aug 18. PMID: 33297046. 5: Li H, Yu S, Cao F, Wang C, Zheng M, Li X, Qiu L. Developmental toxicity and potential mechanisms of pyraoxystrobin to zebrafish (Danio rerio). Ecotoxicol Environ Saf. 2018 Apr 30;151:1-9. doi: 10.1016/j.ecoenv.2017.12.061. Epub 2018 Jan 2. PMID: 29304412. 6: Yang T, Xu C, Liu X, Chen X, Zhang J, Ding X. Fate of a novel strobilurin fungicide pyraoxystrobin in flooded soil. Environ Sci Process Impacts. 2014 May;16(6):1495-500. doi: 10.1039/c3em00706e. PMID: 24752609. 7: Liu X, Chen X, Ding X, Wu H. Uptake and distribution characteristics of the novel fungicide pyraoxystrobin in cucumber plants. RSC Adv. 2018 Jul 30;8(48):27152-27156. doi: 10.1039/c8ra05140b. PMID: 35539991; PMCID: PMC9083277. 8: Chen G, Wang M, Zhu P, Wang G, Hu T. Adverse effects of SYP-3343 on zebrafish development via ROS-mediated mitochondrial dysfunction. J Hazard Mater. 2022 Sep 5;437:129382. doi: 10.1016/j.jhazmat.2022.129382. Epub 2022 Jun 17. PMID: 35749898. 9: Liu X, Wu H, Hu T, Chen X, Ding X. Adsorption and leaching of novel fungicide pyraoxystrobin on soils by 14C tracing method. Environ Monit Assess. 2018 Jan 19;190(2):86. doi: 10.1007/s10661-017-6458-5. PMID: 29349621. 10: Lin LH, Duan MY, Chen G, You XH, Liu CL, Guo XJ. An LC-MS/MS method for determination of novel fungicide pyraoxystrobin in rat plasma and tissues: Toxicokinetics and tissue distribution study. Talanta. 2015 May;136:183-9. doi: 10.1016/j.talanta.2015.01.002. Epub 2015 Jan 12. PMID: 25703001. 11: Lin L, Yu W, Pang Y, Sun C, Meng Q, Li X, Guo X. Validation of an LC-MS/MS method for the quantitative determination of a novel fungicide: pyraoxystrobin in rat plasma and its application to a toxicokinetics study. Anal Bioanal Chem. 2014 Sep;406(22):5521-6. doi: 10.1007/s00216-014-7976-4. Epub 2014 Jun 28. PMID: 24972875. 12: Wang X, Li X, Wang Y, Qin Y, Yan B, Martyniuk CJ. A comprehensive review of strobilurin fungicide toxicity in aquatic species: Emphasis on mode of action from the zebrafish model. Environ Pollut. 2021 Apr 15;275:116671. doi: 10.1016/j.envpol.2021.116671. Epub 2021 Feb 6. PMID: 33582629. 13: Chen L, Song Y, Tang B, Song X, Yang H, Li B, Zhao Y, Huang C, Han X, Wang S, Li Z. Aquatic risk assessment of a novel strobilurin fungicide: A microcosm study compared with the species sensitivity distribution approach. Ecotoxicol Environ Saf. 2015 Oct;120:418-27. doi: 10.1016/j.ecoenv.2015.06.027. Epub 2015 Jun 27. PMID: 26122735. 14: Li H, Hu S, Sun F, Sun Q, Wang N, Li B, Zou N, Lin J, Mu W, Pang X. Residual analysis of QoI fungicides in multiple (six) types of aquatic organisms by UPLC- MS/MS under acutely toxic conditions. Environ Sci Pollut Res Int. 2023 Jan;30(5):12075-12084. doi: 10.1007/s11356-022-22972-3. Epub 2022 Sep 14. PMID: 36104645. 15: Wang LF, Li CM, Xu J, Li H, Su H, Wang J, Jin F, Zhang Y. [Simultaneous determination of 11 strobilurin fungicides in different vegetation types of soil by QuEChERS-ultra performance liquid chromatography-tandem mass spectrometry]. Se Pu. 2018 Aug 8;36(8):730-737. Chinese. doi: 10.3724/SP.J.1123.2018.02020. PMID: 30251495.

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