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MedKoo Cat#: 150115 | Name: Methylpyrrolidone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Methylpyrrolidone is a small molecule acetyl‐lysine mimetic compound with potent immunomodulatory and direct anti‐myeloma activity. Methylpyrrolidone a colorless liquid solvent that is used in many industries and applications such as manufacturing and cleaning.

Chemical Structure

Methylpyrrolidone
Methylpyrrolidone
CAS#872-50-4

Theoretical Analysis

MedKoo Cat#: 150115

Name: Methylpyrrolidone

CAS#: 872-50-4

Chemical Formula: C5H9NO

Exact Mass: 99.0680

Molecular Weight: 99.13

Elemental Analysis: C, 60.58; H, 9.15; N, 14.13; O, 16.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Methylpyrrolidone; 1-METHYL-2-PYRROLIDINONE; N-Methylpyrrolidone; N-Methyl-2-pyrrolidone; 1-methylpyrrolidin-2-one;
IUPAC/Chemical Name
1-methylpyrrolidin-2-one
InChi Key
SECXISVLQFMRJM-UHFFFAOYSA-N
InChi Code
1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3
SMILES Code
O=C1N(C)CCC1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 99.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hilton-Proctor JP, Ilyichova O, Zheng Z, Jennings IG, Johnstone RW, Shortt J, Mountford SJ, Scanlon MJ, Thompson PE. Synthesis and elaboration of N-methylpyrrolidone as an acetamide fragment substitute in bromodomain inhibition. Bioorg Med Chem. 2019 Dec 15;27(24):115157. doi: 10.1016/j.bmc.2019.115157. Epub 2019 Oct 28. PMID: 31727451. 2: Hilton-Proctor JP, Ilyichova O, Zheng Z, Jennings IG, Johnstone RW, Shortt J, Mountford SJ, Scanlon MJ, Thompson PE. Substituted 1-methyl-4-phenylpyrrolidin-2-ones - Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors. Eur J Med Chem. 2020 Apr 1;191:112120. doi: 10.1016/j.ejmech.2020.112120. Epub 2020 Feb 12. PMID: 32120339.