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MedKoo Cat#: 145294 | Name: VNI

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VNI is a potent experimental inhibitor of T. cruzi sterol 14α-demethylase. VNI is nontoxic and highly selective. VNI displays promising pharmacokinetics.

Chemical Structure

VNI
VNI
CAS#1246770-52-4

Theoretical Analysis

MedKoo Cat#: 145294

Name: VNI

CAS#: 1246770-52-4

Chemical Formula: C26H19Cl2N5O2

Exact Mass: 503.0916

Molecular Weight: 504.37

Elemental Analysis: C, 61.92; H, 3.80; Cl, 14.06; N, 13.89; O, 6.34

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
VNI;
IUPAC/Chemical Name
(R)-N-(1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide
InChi Key
CJPLMXOWZZCYHJ-QHCPKHFHSA-N
InChi Code
1S/C26H19Cl2N5O2/c27-20-10-11-21(22(28)14-20)23(15-33-13-12-29-16-33)30-24(34)17-6-8-19(9-7-17)26-32-31-25(35-26)18-4-2-1-3-5-18/h1-14,16,23H,15H2,(H,30,34)/t23-/m0/s1
SMILES Code
ClC1=CC(Cl)=C(C=C1)[C@H](CN2C=CN=C2)NC(=O)C3=CC=C(C=C3)C4=NN=C(O4)C5=CC=CC=C5
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 504.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Polysaccharide diversity in VNI isolates of Cryptococcus neoformans from Roraima, Northern Brazil. Fungal Biol. 2019 Oct;123(10):699-708. doi: 10.1016/j.funbio.2019.06.003. Epub 2019 Jun 12. PMID: 31542188. 6: Siah S, Nakkabi I. Oedème pulmonaire lésionnel par inhalation de vapeurs d’acide phosphorique traité par vni. Ann Burns Fire Disasters. 2017 Dec 31;30(4):278-280. French. 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Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19. N Engl J Med. 2021 Aug 26;385(9):790-802. doi: 10.1056/NEJMoa2105911. Epub 2021 Aug 4. PMID: 34351721; PMCID: PMC8362594. 8: Chidebelu PE, Nweze EI, Meis JF, Cogliati M, Hagen F. Multi-locus sequence typing reveals genotypic similarity in Nigerian Cryptococcus neoformans AFLP1/VNI of environmental and clinical origin. J Med Microbiol. 2021 Oct;70(10). doi: 10.1099/jmm.0.001440. PMID: 34665109. 9: Bive BZ, Sacheli R, Mudogo CN, Zakayi PK, Bontems S, Lelo GM, Hayette MP. Correlation of antifungal susceptibility and sequence types within Cryptococcus neoformans VNI from HIV patients, and ERG11 gene polymorphism. J Mycol Med. 2023 Nov;33(4):101428. doi: 10.1016/j.mycmed.2023.101428. Epub 2023 Aug 25. PMID: 37651769. 10: Vélez N, Vega-Vela N, Muñoz M, Gómez P, Escandón P, Ramírez JD, Zaragoza O, Monteoliva Diaz L, Parra-Giraldo CM. 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PMID: 34927938. 13: Melhem MSC, Leite Júnior DP, Takahashi JPF, Macioni MB, Oliveira L, de Araújo LS, Fava WS, Bonfietti LX, Paniago AMM, Venturini J, Espinel-Ingroff A. Antifungal Resistance in Cryptococcal Infections. Pathogens. 2024 Jan 29;13(2):128. doi: 10.3390/pathogens13020128. PMID: 38392866; PMCID: PMC10891860. 14: Brinjikji W, Iyer VN, Sorenson T, Lanzino G. Cerebrovascular Manifestations of Hereditary Hemorrhagic Telangiectasia. Stroke. 2015 Nov;46(11):3329-37. doi: 10.1161/STROKEAHA.115.010984. Epub 2015 Sep 24. Erratum in: Stroke. 2015 Nov;46(11):e247. doi: 10.1161/STR.0000000000000082. PMID: 26405205. 15: Blum K, Elman I, Bowirrat A, Baron D, Thanos PK, Hanna C, Badgaiyan RD, Gold MS. Futuristic Exploration of Addiction Neuroscience in the Genomic Era. Psychol Res Behav Manag. 2023 Dec 9;16:4989-4991. doi: 10.2147/PRBM.S439837. PMID: 38094658; PMCID: PMC10717929. 16: Friggeri L, Hargrove TY, Wawrzak Z, Blobaum AL, Rachakonda G, Lindsley CW, Villalta F, Nes WD, Botta M, Guengerich FP, Lepesheva GI. Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis. J Med Chem. 2018 Jul 12;61(13):5679-5691. doi: 10.1021/acs.jmedchem.8b00641. Epub 2018 Jun 25. PMID: 29894182; PMCID: PMC6176729. 17: Fang W, Fa Z, Liao W. Epidemiology of Cryptococcus and cryptococcosis in China. Fungal Genet Biol. 2015 May;78:7-15. doi: 10.1016/j.fgb.2014.10.017. Epub 2014 Nov 7. PMID: 25445309. 18: Sottiaux T, Roeseler J, Palavecino L, Delguste P, Parreira VF, Reynaert M. La ventilation non invasive à deux niveaux de pression (VNI-2P ou Bi-PAP) [Noninvasive ventilation at 2 pressure levels (VNI-2P or Bi-PAP)]. Rev Med Liege. 1996 Oct;51(10):635-8. French. PMID: 8984558. 19: Rocha DFS, Cruz KS, Santos CSDS, Menescal LSF, Neto JRDS, Pinheiro SB, Silva LM, Trilles L, Braga de Souza JV. MLST reveals a clonal population structure for Cryptococcus neoformans molecular type VNI isolates from clinical sources in Amazonas, Northern-Brazil. PLoS One. 2018 Jun 8;13(6):e0197841. doi: 10.1371/journal.pone.0197841. PMID: 29883489; PMCID: PMC5993295. 20: Nishikawa MM, Almeida-Paes R, Brito-Santos F, Nascimento CR, Fialho MM, Trilles L, Morales BP, da Silva SA, Santos W, Santos LO, Fortes ST, Cardarelli- Leite P, Lázera MDS. Comparative antifungal susceptibility analyses of Cryptococcus neoformans VNI and Cryptococcus gattii VGII from the Brazilian Amazon Region by the Etest, Vitek 2, and the Clinical and Laboratory Standards Institute broth microdilution methods. Med Mycol. 2019 Oct 1;57(7):864-873. doi: 10.1093/mmy/myy150. PMID: 30657975.