MedKoo Cat#: 408201 | Name: M4K2308

Description:

WARNING: This product is for research use only, not for human or veterinary use.

M4K2308 is an analog of M4K2281, is a potent and selective ALK2 inhibitor. Compared to M4K2281, M4K2308 is a demethyl version, and the methyl group in piperidine ring was removed. Both M4K2308 and M4K2281 show impressive levels of potency against ALK2 in both the biochemical and cellular assays.

Chemical Structure

M4K2308
M4K2308
CAS#3034840-18-8

Theoretical Analysis

MedKoo Cat#: 408201

Name: M4K2308

CAS#: 3034840-18-8

Chemical Formula: C26H29N3O4

Exact Mass: 447.2158

Molecular Weight: 447.54

Elemental Analysis: C, 69.78; H, 6.53; N, 9.39; O, 14.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
M4K2308; M4-K2308; M4 K2308;
IUPAC/Chemical Name
9-(piperazin-1-yl)-4-(3,4,5-trimethoxyphenyl)-5,6-dihydrobenzo[2,3]oxepino[4,5-c]pyridine
InChi Key
QFFKJPJEWNRMHC-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H29N3O4/c1-30-24-12-17(13-25(31-2)26(24)32-3)21-15-28-16-22-19(21)6-11-33-23-14-18(4-5-20(22)23)29-9-7-27-8-10-29/h4-5,12-16,27H,6-11H2,1-3H3
SMILES Code
N1=CC(C2=CC(OC)=C(OC)C(OC)=C2)=C3C(=C1)C4=CC=C(C=C4OCC3)N5CCNCC5
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 447.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
González-Álvarez H, Ensan D, Xin T, Wong JF, Zepeda-Velázquez CA, Cros J, Hoffer L, Kiyota T, Wilson BJ, Aman A, Roberts O, Isaac MB, Bullock AN, Smil D, Al-Awar R. Discovery of Conformationally Constrained ALK2 Inhibitors. J Med Chem. 2024 Mar 18. doi: 10.1021/acs.jmedchem.3c02308. Epub ahead of print. PMID: 38498998.