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MedKoo Cat#: 150079 | Name: Erythromycin B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Erythromycin B is an erythromycin that consists of erythronolide B having 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl and 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl residues attached at positions 4 and 6 respectively.

Chemical Structure

Erythromycin B
Erythromycin B
CAS#527-75-3

Theoretical Analysis

MedKoo Cat#: 150079

Name: Erythromycin B

CAS#: 527-75-3

Chemical Formula: C37H67NO12

Exact Mass: 717.4660

Molecular Weight: 717.94

Elemental Analysis: C, 61.90; H, 9.41; N, 1.95; O, 26.74

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Erythromycin B; Berythromycin; 12-Deoxyerythromycin; Beritromicina;
IUPAC/Chemical Name
(3R,4S,5S,6R,7R,9R,11R,12S,13R,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione
InChi Key
IDRYSCOQVVUBIJ-PPGFLMPOSA-N
InChi Code
1S/C37H67NO12/c1-14-26-20(4)29(40)21(5)28(39)18(2)16-36(9,44)33(50-35-30(41)25(38(11)12)15-19(3)46-35)22(6)31(23(7)34(43)48-26)49-27-17-37(10,45-13)32(42)24(8)47-27/h18-27,29-33,35,40-42,44H,14-17H2,1-13H3/t18-,19-,20+,21+,22+,23-,24+,25+,26-,27+,29+,30-,31+,32+,33-,35+,36-,37-/m1/s1
SMILES Code
CN(C)[C@H]([C@H]([C@@H]1O[C@H]([C@H]([C@@H]([C@H](C2=O)C)O[C@H]3C[C@](C)([C@H]([C@@H](O3)C)O)OC)C)[C@@](C)(C[C@H](C([C@@H]([C@H]([C@H]([C@H](O2)CC)C)O)C)=O)C)O)O)C[C@H](O1)C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 717.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bhadra PK, Hassanzadeh A, Arsic B, Allison DG, Morris GA, Barber J. Enhancement of the properties of a drug by mono-deuteriation: reduction of acid- catalysed formation of a gut-motilide enol ether from 8-deuterio-erythromycin B. Org Biomol Chem. 2016 Jul 14;14(26):6289-96. doi: 10.1039/c6ob00785f. Epub 2016 Jun 7. PMID: 27273525. 2: Bhadra PK, Magwaza RN, Nirmalan N, Freeman S, Barber J, Arsic B. Selected Derivatives of Erythromycin B-In Silico and Anti-Malarial Studies. Materials (Basel). 2021 Nov 18;14(22):6980. doi: 10.3390/ma14226980. PMID: 34832380; PMCID: PMC8618316. 3: Kurath P, Jones PH, Egan RS, Perun TJ. Acid degradation of erythromycin A and erythromycin B. Experientia. 1971 Apr 15;27(4):362. doi: 10.1007/BF02137246. PMID: 5581079. 4: Zhang Q, Wu J, Qian J, Chu J, Zhuang Y, Zhang S, Liu W. Knocking out of tailoring genes eryK and eryG in an industrial erythromycin-producing strain of Saccharopolyspora erythraea leading to overproduction of erythromycin B, C and D at different conversion ratios. Lett Appl Microbiol. 2011 Feb;52(2):129-37. doi: 10.1111/j.1472-765X.2010.02973.x. Epub 2010 Dec 22. PMID: 21175699. 5: Mordi MN, Pelta MD, Boote V, Morris GA, Barber J. Acid-catalyzed degradation of clarithromycin and erythromycin B: a comparative study using NMR spectroscopy. J Med Chem. 2000 Feb 10;43(3):467-74. doi: 10.1021/jm9904811. PMID: 10669574. 6: National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 9918244, Erythromycin B. Retrieved July 11, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Erythromycin-B.