SMBT-1 | CAS#2410554-04-8 | biochemical

MedKoo Cat#: 145265 | Name: SMBT-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SMBT-1 is often radiolabeled with 18F in order for research purposes. 18F-SMBT-1 is a novel 18F PET tracer highly selective for MAO-B. 18F-SMBT-1 is a promising and selective MAO-B PET tracer candidate, which can be useful for quantitative monitoring of astrogliosis in the human brain.

Chemical Structure

SMBT-1

CAS#2410554-04-8

Theoretical Analysis

MedKoo Cat#: 145265

Name: SMBT-1

CAS#: 2410554-04-8

Chemical Formula: C18H17FN2O2

Exact Mass: 312.1274

Molecular Weight: 312.34

Elemental Analysis: C, 69.22; H, 5.49; F, 6.08; N, 8.97; O, 10.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

SMBT-1; SMBT1; SMBT 1; THK-5470;

IUPAC/Chemical Name

(S)-1-fluoro-3-((2-(6-methylpyridin-3-yl)quinolin-6-yl)oxy)propan-2-ol

InChi Key

FBXCMFBJUZVBJS-OAHLLOKOSA-N

InChi Code

1S/C18H17FN2O2/c1-12-2-3-14(10-20-12)18-6-4-13-8-16(5-7-17(13)21-18)23-11-15(22)9-19/h2-8,10,15,22H,9,11H2,1H3/t15-/m1/s1

SMILES Code

CC1=NC=C(C=C1)C2=NC3=C(C=C2)C=C(OC[C@H](O)CF)C=C3

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 312.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Harada R, Hayakawa Y, Ezura M, Lerdsirisuk P, Du Y, Ishikawa Y, Iwata R, Shidahara M, Ishiki A, Kikuchi A, Arai H, Kudo Y, Yanai K, Furumoto S, Okamura N. 18F-SMBT-1: A Selective and Reversible PET Tracer for Monoamine Oxidase-B Imaging. J Nucl Med. 2021 Feb;62(2):253-258. doi: 10.2967/jnumed.120.244400. Epub 2020 Jul 9. PMID: 32646880. 2: Villemagne VL, Harada R, Doré V, Furumoto S, Mulligan R, Kudo Y, Burnham S, Krishnadas N, Bourgeat P, Xia Y, Laws S, Bozinovski S, Huang K, Ikonomovic MD, Fripp J, Yanai K, Okamura N, Rowe CC. Assessing Reactive Astrogliosis with 18F-SMBT-1 Across the Alzheimer Disease Spectrum. J Nucl Med. 2022 Oct;63(10):1560-1569. doi: 10.2967/jnumed.121.263255. Epub 2022 Jan 27. PMID: 35086892; PMCID: PMC9536709. 3: Harada R, Shimizu Y, Du Y, Ishikawa Y, Iwata R, Kudo Y, Yanai K, Okamura N, Furumoto S. The Role of Chirality of [18F]SMBT-1 in Imaging of Monoamine Oxidase-B. ACS Chem Neurosci. 2022 Feb 2;13(3):322-329. doi: 10.1021/acschemneuro.1c00655. Epub 2022 Jan 20. PMID: 35049267. 4: Villemagne VL, Harada R, Doré V, Furumoto S, Mulligan R, Kudo Y, Burnham S, Krishnadas N, Bozinovski S, Huang K, Lopresti BJ, Yanai K, Rowe CC, Okamura N. First-in-Humans Evaluation of 18F-SMBT-1, a Novel 18F-Labeled Monoamine Oxidase-B PET Tracer for Imaging Reactive Astrogliosis. J Nucl Med. 2022 Oct;63(10):1551-1559. doi: 10.2967/jnumed.121.263254. Epub 2022 Jan 27. PMID: 35086898; PMCID: PMC9536703. 5: Chatterjee P, Doré V, Pedrini S, Krishnadas N, Thota R, Bourgeat P, Ikonomovic MD, Rainey-Smith SR, Burnham SC, Fowler C, Taddei K, Mulligan R, Ames D, Masters CL, Fripp J, Rowe CC, Martins RN, Villemagne VL; The AIBL Research Group. Plasma Glial Fibrillary Acidic Protein Is Associated with 18F-SMBT-1 PET: Two Putative Astrocyte Reactivity Biomarkers for Alzheimer's Disease. J Alzheimers Dis. 2023;92(2):615-628. doi: 10.3233/JAD-220908. PMID: 36776057; PMCID: PMC10041433. 6: Kong Y, Maschio CA, Shi X, Xie F, Zuo C, Konietzko U, Shi K, Rominger A, Xiao J, Huang Q, Nitsch RM, Guan Y, Ni R. Relationship Between Reactive Astrocytes, by [18F]SMBT-1 Imaging, with Amyloid-Beta, Tau, Glucose Metabolism, and TSPO in Mouse Models of Alzheimer's Disease. Mol Neurobiol. 2024 Mar 19. doi: 10.1007/s12035-024-04106-7. Epub ahead of print. PMID: 38502413. 7: Fontana IC, Scarpa M, Malarte ML, Rocha FM, Ausellé-Bosch S, Bluma M, Bucci M, Chiotis K, Kumar A, Nordberg A. Astrocyte Signature in Alzheimer's Disease Continuum through a Multi-PET Tracer Imaging Perspective. Cells. 2023 May 24;12(11):1469. doi: 10.3390/cells12111469. PMID: 37296589; PMCID: PMC10253101. 8: Harada R. [Imaging of neuropathology by PET tracers]. Nihon Yakurigaku Zasshi. 2022;157(6):453-457. Japanese. doi: 10.1254/fpj.22061. PMID: 36328560. 9: Lopresti BJ, Stehouwer J, Reese AC, Mason NS, Royse SK, Narendran R, Laymon CM, Lopez OL, Cohen AD, Mathis CA, Villemagne VL. Kinetic modeling of the monoamine oxidase-B radioligand [18F]SMBT-1 in human brain with positron emission tomography. J Cereb Blood Flow Metab. 2024 May 12:271678X241254679. doi: 10.1177/0271678X241254679. Epub ahead of print. PMID: 38735059. 10: Fontana IC, Kumar A, Okamura N, Nordberg A. Multitracer Approach to Understanding the Complexity of Reactive Astrogliosis in Alzheimer's Brains. ACS Chem Neurosci. 2024 Jan 17;15(2):328-336. doi: 10.1021/acschemneuro.3c00646. Epub 2023 Dec 22. PMID: 38133820; PMCID: PMC10797624. 11: Kong Y, Cao L, Wang J, Zhuang J, Xie F, Zuo C, Huang Q, Shi K, Rominger A, Li M, Wu P, Guan Y, Ni R. In vivo reactive astrocyte imaging using [18F]SMBT-1 in tauopathy and familial Alzheimer's disease mouse models: A multi-tracer study. J Neurol Sci. 2024 Jul 15;462:123079. doi: 10.1016/j.jns.2024.123079. Epub 2024 Jun 4. PMID: 38878650. 12: Harada R, Furumoto S, Kudo Y, Yanai K, Villemagne VL, Okamura N. Imaging of Reactive Astrogliosis by Positron Emission Tomography. Front Neurosci. 2022 Feb 8;16:807435. doi: 10.3389/fnins.2022.807435. PMID: 35210989; PMCID: PMC8862631. 13: Kumar A, Fontana IC, Nordberg A. Reactive astrogliosis: A friend or foe in the pathogenesis of Alzheimer's disease. J Neurochem. 2023 Feb;164(3):309-324. doi: 10.1111/jnc.15565. Epub 2022 Jan 7. PMID: 34931315. 14: Rodriguez-Vieitez E, Kumar A, Malarte ML, Ioannou K, Rocha FM, Chiotis K. Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach. Methods Mol Biol. 2024;2785:195-218. doi: 10.1007/978-1-0716-3774-6_13. PMID: 38427196.