3-Iodo-L-tyrosine | CAS#70-78-0 | Iodotyrosine

MedKoo Cat#: 150069 | Name: 3-Iodo-L-tyrosine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

3-Iodo-L-tyrosine is an intermediate in the synthesis of thyroid hormones. 3-Iodo-L-tyrosine has been used as an inhibitor for tyrosine hydroxylase enzyme.

Chemical Structure

3-Iodo-L-tyrosine

CAS#70-78-0

Theoretical Analysis

MedKoo Cat#: 150069

Name: 3-Iodo-L-tyrosine

CAS#: 70-78-0

Chemical Formula: C9H10INO3

Exact Mass: 306.9705

Molecular Weight: 307.09

Elemental Analysis: C, 35.20; H, 3.28; I, 41.33; N, 4.56; O, 15.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

3-Iodo-L-tyrosine; 3-Iodo L tyrosine; 3-IodoLtyrosine; 3-IODOTYROSINE;

IUPAC/Chemical Name

(2S)-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic acid

InChi Key

UQTZMGFTRHFAAM-ZETCQYMHSA-N

InChi Code

1S/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1

SMILES Code

O=C(O)[C@@H](N)CC1=CC=C(O)C(I)=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 307.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Fernández-Espejo E, Bis-Humbert C. Excess amounts of 3-iodo-l-tyrosine induce Parkinson-like features in experimental approaches of Parkinsonism. Neurotoxicology. 2018 Jul;67:178-189. doi: 10.1016/j.neuro.2018.06.002. Epub 2018 Jun 6. PMID: 29885340. 2: Thoener J, König C, Weiglein A, Toshima N, Mancini N, Amin F, Schleyer M. Associative learning in larval and adult Drosophila is impaired by the dopamine- synthesis inhibitor 3-Iodo-L-tyrosine. Biol Open. 2021 Jun 15;10(6):bio058198. doi: 10.1242/bio.058198. Epub 2021 Jun 9. PMID: 34106227; PMCID: PMC8214425. 3: Sakamoto K, Murayama K, Oki K, Iraha F, Kato-Murayama M, Takahashi M, Ohtake K, Kobayashi T, Kuramitsu S, Shirouzu M, Yokoyama S. Genetic encoding of 3-iodo- L-tyrosine in Escherichia coli for single-wavelength anomalous dispersion phasing in protein crystallography. Structure. 2009 Mar 11;17(3):335-44. doi: 10.1016/j.str.2009.01.008. PMID: 19278648. 4: Walker WH 4th, Rokita SE. Use of a boroxazolidone complex of 3-iodo-L- tyrosine for palladium-catalyzed cross-coupling. J Org Chem. 2003 Feb 21;68(4):1563-6. doi: 10.1021/jo0207022. PMID: 12585904. 5: Ness DK, Foley GL, Villar D, Hansen LG. Effects of 3-iodo-L-tyrosine, a tyrosine hydroxylase inhibitor, on eye pigmentation and biogenic amines in the planarian, Dugesia dorotocephala. Fundam Appl Toxicol. 1996 Apr;30(2):153-61. doi: 10.1006/faat.1996.0052. PMID: 8812261.