PF-1367550 | CAS#319461-60-4 | JAK inhibitor

MedKoo Cat#: 145247 | Name: PF-1367550

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF-1367550 is a novel JAK inhibitor. PF-1367550 is more potent than PF956980.

Chemical Structure

PF-1367550

CAS#319461-60-4

Theoretical Analysis

MedKoo Cat#: 145247

Name: PF-1367550

CAS#: 319461-60-4

Chemical Formula: C22H18N4O

Exact Mass: 354.1481

Molecular Weight: 354.41

Elemental Analysis: C, 74.56; H, 5.12; N, 15.81; O, 4.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

PF-1367550; PF1367550; PF 1367550;

IUPAC/Chemical Name

4-(3-(1H-benzo[d]imidazol-2-yl)-1H-indazol-6-yl)-3-ethylphenol

InChi Key

CSLGOZXFBHTYAA-UHFFFAOYSA-N

InChi Code

1S/C22H18N4O/c1-2-13-11-15(27)8-10-16(13)14-7-9-17-20(12-14)25-26-21(17)22-23-18-5-3-4-6-19(18)24-22/h3-12,27H,2H2,1H3,(H,23,24)(H,25,26)

SMILES Code

CCC1=C(C=CC(O)=C1)C2=CC=C3C(NN=C3C4=NC5=CC=CC=C5N4)=C2

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 354.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Fenwick PS, Macedo P, Kilty IC, Barnes PJ, Donnelly LE. Effect of JAK Inhibitors on Release of CXCL9, CXCL10 and CXCL11 from Human Airway Epithelial Cells. PLoS One. 2015 Jun 19;10(6):e0128757. doi: 10.1371/journal.pone.0128757. PMID: 26090665; PMCID: PMC4474874.