MedKoo Cat#: 127364 | Name: ARV-393
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

ARV-393 is an orally active PROTAC that utilizes the ubiquitin-proteasome system to target the degradation of BCL6.

Chemical Structure

ARV-393
ARV-393
CAS#2851885-95-3

Theoretical Analysis

MedKoo Cat#: 127364

Name: ARV-393

CAS#: 2851885-95-3

Chemical Formula: C46H53ClFN9O7

Exact Mass: 897.3741

Molecular Weight: 898.43

Elemental Analysis: C, 61.50; H, 5.95; Cl, 3.95; F, 2.11; N, 14.03; O, 12.47

Price and Availability

Size Price Availability Quantity
10mg USD 950.00 2 Weeks
25mg USD 1,950.00 2 Weeks
50mg USD 2,950.00 2 Weeks
100mg USD 4,650.00 2 Weeks
1g USD 12,950.00 2 Weeks
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Related CAS #
No Data
Synonym
ARV-393; ARV 393; ARV393
IUPAC/Chemical Name
2-((6-((5-chloro-2-(4-(3-(4-(2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxoisoindolin-5-yl)piperidin-1-yl)cyclobutoxy)piperidin-1-yl)pyrimidin-4-yl)amino)-1-isopropyl-2-oxo-1,2-dihydroquinolin-3-yl)oxy)-N-methylacetamide
InChi Key
ZOGOEUHUEFKKTD-UHFFFAOYSA-N
InChi Code
InChI=1S/C46H53ClFN9O7/c1-25(2)57-36-7-4-28(18-27(36)19-38(45(57)62)63-24-40(59)49-3)51-42-35(47)22-50-46(53-42)55-16-12-30(13-17-55)64-31-20-29(21-31)54-14-10-26(11-15-54)32-5-6-33-34(41(32)48)23-56(44(33)61)37-8-9-39(58)52-43(37)60/h4-7,18-19,22,25-26,29-31,37H,8-17,20-21,23-24H2,1-3H3,(H,49,59)(H,50,51,53)(H,52,58,60)
SMILES Code
CC(C)N1C2=C(C=C(C=C2)NC3=NC(=NC=C3Cl)N4CCC(CC4)OC5CC(C5)N6CCC(CC6)C7=C(C8=C(C=C7)C(=O)N(C8)C9CCC(=O)NC9=O)F)C=C(C1=O)OCC(=O)NC
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 898.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL