Histamine blocker 12 | H2 blocker

MedKoo Cat#: 150054 | Name: Histamine blocker 12

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Histamine blocker 12 is a H2S-releasing bifunctional histamine blocker or H2 blocker that exhibits superior antipruritic action and limited side effects.

Chemical Structure

Histamine blocker 12

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 150054

Name: Histamine blocker 12

CAS#: N/A

Chemical Formula: C32H36ClN3O5S

Exact Mass: 609.2060

Molecular Weight: 610.17

Elemental Analysis: C, 62.99; H, 5.95; Cl, 5.81; N, 6.89; O, 13.11; S, 5.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Histamine blocker 12; Histamine blocker-12; Histamine blocker12;

IUPAC/Chemical Name

4-Carbamothioylphenyl (2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethyl) succinate

InChi Key

WLRIVZRRAKUQFW-UHFFFAOYSA-N

InChi Code

1S/C32H36ClN3O5S/c33-27-10-6-25(7-11-27)31(24-4-2-1-3-5-24)36-18-16-35(17-19-36)20-21-39-22-23-40-29(37)14-15-30(38)41-28-12-8-26(9-13-28)32(34)42/h1-13,31H,14-23H2,(H2,34,42)

SMILES Code

O=C(OCCOCCN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1)CCC(OC4=CC=C(C(N)=S)C=C4)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 610.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Antoniadou I, Georgiou M, Dotsikas Y, Lamprou A, Lougiakis N, Pouli N, Karousis N, Loukas Y, Tseti I, Marakos P, Papapetropoulos A. Novel H2S-Releasing Bifunctional Antihistamine Molecules with Improved Antipruritic and Reduced Sedative Actions. J Med Chem. 2023 Jul 27;66(14):9607-9621. doi: 10.1021/acs.jmedchem.3c00321. Epub 2023 Jul 6. PMID: 37409873.