HER-PS-I is designed based on the FDA-approved HER2 inhibitor lapatinib to efficiently degrade HER2 together with its interacting protein partner HER3, which is thought to induce HER2-targeted therapy resistance and difficult to target by small molecules. HER-PS-I exhibits excellent anticancer activity against drug-resistant MDA-MB-453 cells
MedKoo Cat#: 150052
Name: HER-PS-I
CAS#: N/A
Chemical Formula: C36H27ClFIN4OS2
Exact Mass: 776.0340
Molecular Weight: 777.11
Elemental Analysis: C, 55.64; H, 3.50; Cl, 4.56; F, 2.44; I, 16.33; N, 7.21; O, 2.06; S, 8.25
The following data is based on the product molecular weight 777.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
