MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 145230 | Name: Fluazifop

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fluazifop, the major chiral metabolite of fluazifop-butyl. Formation of fluazifop in soil is rapidly accompanied with the fast degradation of fluazifop-butyl. The S-enantiomer of fluazifop is degraded at a much higher rate than the R-enantiomer. The selective mode of action of fluazifop is the inhibition of fatty acid synthesis de novo.

Chemical Structure

Fluazifop
Fluazifop
CAS#69335-91-7

Theoretical Analysis

MedKoo Cat#: 145230

Name: Fluazifop

CAS#: 69335-91-7

Chemical Formula: C15H12F3NO4

Exact Mass: 327.0718

Molecular Weight: 327.26

Elemental Analysis: C, 55.05; H, 3.70; F, 17.42; N, 4.28; O, 19.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Fluazifop;
IUPAC/Chemical Name
2-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenoxy)propanoic acid
InChi Key
YUVKUEAFAVKILW-UHFFFAOYSA-N
InChi Code
1S/C15H12F3NO4/c1-9(14(20)21)22-11-3-5-12(6-4-11)23-13-7-2-10(8-19-13)15(16,17)18/h2-9H,1H3,(H,20,21)
SMILES Code
CC(OC1=CC=C(OC2=CC=C(C=N2)C(F)(F)F)C=C1)C(O)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 327.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu Z, Li P, Sun X, Zhou F, Yang C, Li L, Matsumoto H, Luo X. Fluazifop-P- butyl induced ROS generation with IAA (indole-3-acetic acid) oxidation in Acanthospermum hispidum D.C. Pestic Biochem Physiol. 2017 Nov;143:312-318. doi: 10.1016/j.pestbp.2017.10.005. Epub 2017 Oct 26. PMID: 29183607. 2: Qi Y, Liu D, Liu C, Liang Y, Zhan J, Zhou Z, Wang P. Enantioselective behaviour of the herbicide fluazifop-butyl in vegetables and soil. Food Chem. 2017 Apr 15;221:1120-1127. doi: 10.1016/j.foodchem.2016.11.048. Epub 2016 Nov 10. PMID: 27979068. 3: Qi Y, Liu D, Luo M, Jing X, Wang P, Zhou Z. Enantioselective degradation and chiral stability of the herbicide fluazifop-butyl in soil and water. Chemosphere. 2016 Mar;146:315-22. doi: 10.1016/j.chemosphere.2015.12.040. Epub 2015 Dec 28. PMID: 26735732. 4: Woollen BH, Hart TB, Batten PL, Laird WJ, Davies DS, Dollery CT. Oral pharmacokinetics of fluazifop-butyl in human volunteers. Hum Exp Toxicol. 1991 Jan;10(1):39-43. doi: 10.1177/096032719101000107. PMID: 1673623. 5: Ramsey JD, Woollen BH, Auton TR, Batten PL, Leeser JE. Pharmacokinetics of fluazifop-butyl in human volunteers. II: Dermal dosing. Hum Exp Toxicol. 1992 Jul;11(4):247-54. doi: 10.1177/096032719201100402. PMID: 1354971. 6: Blake RJ, Westbury DB, Woodcock BA, Sutton P, Potts SG. Investigating the phytotoxicity of the graminicide fluazifop-P-butyl against native UK wildflower species. Pest Manag Sci. 2012 Mar;68(3):412-21. doi: 10.1002/ps.2282. Epub 2011 Oct 3. PMID: 21972119. 7: Li G, Hou Z, Zhang R, Chen X, Lu Z. Nanometer Titanium Dioxide Mediated High Efficiency Photodegradation of Fluazifop-p-Butyl. Int J Environ Res Public Health. 2019 Sep 26;16(19):3600. doi: 10.3390/ijerph16193600. PMID: 31561447; PMCID: PMC6801646. 8: Ore A, Olayinka ET. Fluazifop- p-butyl, an aryloxyphenoxypropionate herbicide, diminishes renal and hepatic functions and triggers testicular oxidative stress in orally exposed rats. Toxicol Ind Health. 2017 May;33(5):406-415. doi: 10.1177/0748233716657763. Epub 2016 Jul 4. PMID: 27378613. 9: Shang Y, Yang C, Liu Z, Song J, Li P, Li L, Zhou F, Xin H, Wan F, Matsumoto H, Luo X. New evidence for primordial action site of Fluazifop-P-butyl on Acanthospermum hispidum seedlings: From the effects on chlorophyll fluorescence characteristics and histological observation. Pestic Biochem Physiol. 2017 Oct;142:170-175. doi: 10.1016/j.pestbp.2017.07.006. Epub 2017 Jul 21. PMID: 29107243. 10: Lackmann C, Velki M, Seiler TB, Hollert H. Herbicides diuron and fluazifop- p-butyl affect avoidance response and multixenobiotic resistance activity in earthworm Eisenia andrei. Chemosphere. 2018 Nov;210:110-119. doi: 10.1016/j.chemosphere.2018.07.008. Epub 2018 Jul 2. PMID: 29986216. 11: Li G, Li S, Liu C, Jiang J. Effect of main inorganic metal elements in Panax ginseng field soil on the photodegradation of fluazifop-p-butyl. Environ Sci Pollut Res Int. 2021 Oct;28(38):52901-52912. doi: 10.1007/s11356-021-14091-2. Epub 2021 May 21. PMID: 34018113. 12: Chronopoulou E, Madesis P, Asimakopoulou B, Platis D, Tsaftaris A, Labrou NE. Catalytic and structural diversity of the fluazifop-inducible glutathione transferases from Phaseolus vulgaris. Planta. 2012 Jun;235(6):1253-69. doi: 10.1007/s00425-011-1572-z. Epub 2011 Dec 28. PMID: 22203322. 13: Nègre M, Gennari M, Andreoni V, Ambrosoli R, Celi L. Microbial metabolism of fluazifop-butyl. J Environ Sci Health B. 1993 Oct;28(5):545-76. doi: 10.1080/03601239309372841. PMID: 8409232. 14: Walker KA, Ridley SM, Harwood JL. Effects of the selective herbicide fluazifop on fatty acid synthesis in pea (Pisum sativum) and barley (Hordeum vulgare). Biochem J. 1988 Sep 15;254(3):811-7. doi: 10.1042/bj2540811. PMID: 3196294; PMCID: PMC1135155. 15: Fan S, Zhang F, Deng K, Yu C, Liu S, Zhao P, Pan C. Spinach or amaranth contains highest residue of metalaxyl, fluazifop-P-butyl, chlorpyrifos, and lambda-cyhalothrin on six leaf vegetables upon open field application. J Agric Food Chem. 2013 Mar 6;61(9):2039-44. doi: 10.1021/jf304710u. Epub 2013 Feb 22. PMID: 23387923. 16: Badawi N, Rosenbom AE, Olsen P, Sørensen SR. Environmental Fate of the Herbicide Fluazifop-P-butyl and Its Degradation Products in Two Loamy Agricultural Soils: A Combined Laboratory and Field Study. Environ Sci Technol. 2015 Aug 4;49(15):8995-9003. doi: 10.1021/acs.est.5b00406. Epub 2015 Jul 15. PMID: 26147883. 17: Cha TS, Najihah MG, Sahid IB, Chuah TS. Molecular basis for resistance to ACCase-inhibiting fluazifop in Eleusine indica from Malaysia. Pestic Biochem Physiol. 2014 May;111:7-13. doi: 10.1016/j.pestbp.2014.04.011. Epub 2014 May 6. PMID: 24861927. 18: Vendelboe AL, Norgaard T, Olsen P, de Jonge LW, Rosenbom AE. When does the fluazifop-P-butyl degradate, TFMP, leach through an agricultural loamy soil to groundwater? Sci Total Environ. 2016 Aug 15;562:1044-1053. doi: 10.1016/j.scitotenv.2016.04.182. Epub 2016 May 6. PMID: 27157530. 19: Worobey BL, Shields JB. Determination of fluazifop-butyl and fluazifop acid in soybeans and soybean oil using liquid chromatography with oxidative amperometric detection. J Assoc Off Anal Chem. 1989 Mar-Apr;72(2):368-71. PMID: 2708288. 20: Kostka G, Palut D, Ludwicki JK, Kopeć-Szlezak J, Wiadrowska B, Lembowicz K. Hepatocellular peroxisome proliferation and DNA synthesis in Wistar rats treated with herbicide fluazifop. Toxicology. 2002 Sep 16;178(3):221-8. doi: 10.1016/s0300-483x(02)00234-2. PMID: 12167308.