Synonym
Asperidine B; Asperidine-B;
IUPAC/Chemical Name
(2S,3S,6R)-2-Benzyl-1-methyl-6-octylpiperidin-3-ol
InChi Key
IFEQGXBZTSVFMN-HKBOAZHASA-N
InChi Code
1S/C21H35NO/c1-3-4-5-6-7-11-14-19-15-16-21(23)20(22(19)2)17-18-12-9-8-10-13-18/h8-10,12-13,19-21,23H,3-7,11,14-17H2,1-2H3/t19-,20+,21+/m1/s1
SMILES Code
O[C@@H]1[C@H](CC2=CC=CC=C2)N(C)[C@H](CCCCCCCC)CC1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
317.52
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Ontawong A, Duangjai A, Sukpondma Y, Tadpetch K, Muanprasat C, Rukachaisirikul V, Inchai J, Vaddhanaphuti CS. Cholesterol-Lowering Effects of Asperidine B, a Pyrrolidine Derivative from the Soil-Derived Fungus Aspergillus sclerotiorum PSU-RSPG178: A Potential Cholesterol Absorption Inhibitor. Pharmaceuticals (Basel). 2022 Jul 31;15(8):955. doi: 10.3390/ph15080955. PMID: 36015103; PMCID: PMC9414821.
2: Thongpat K, Holasut P, Ontawong A, Inchai J, Duangjai A, Rukachaisirikul V, Vaddhanaphuti CS, Tadpetch K. Synthesis and potential antidiabetic and lipid- lowering activities of putative asperidine B and its desmethyl analogue. Bioorg Med Chem Lett. 2023 Sep 1;93:129437. doi: 10.1016/j.bmcl.2023.129437. Epub 2023 Aug 6. PMID: 37549851.
3: Duangjai A, Rukachaisirikul V, Sukpondma Y, Srimaroeng C, Muanprasat C. Antispasmodic Effect of Asperidine B, a Pyrrolidine Derivative, through Inhibition of L-Type Ca2+ Channel in Rat Ileal Smooth Muscle. Molecules. 2021 Sep 9;26(18):5492. doi: 10.3390/molecules26185492. PMID: 34576962; PMCID: PMC8470553.
