SHR5428 is a selective and noncovalent inhibitor of CDK7. SHR5428 demonstrates highly potent CDK7 enzymatic activity and triple negative breast cancer cellular activity on MDA-MB-468 cell. SHR5428 also displays favorable pharmacokinetic properties in different preclinical species.
MedKoo Cat#: 150040
Name: SHR5428
CAS#: N/A
Chemical Formula: C22H23F3N5O2P
Exact Mass: 477.1540
Molecular Weight: 477.43
Elemental Analysis: C, 55.35; H, 4.86; F, 11.94; N, 14.67; O, 6.70; P, 6.49
The following data is based on the product molecular weight 477.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
