BIO-1790735 | OGA ligand

MedKoo Cat#: 150008 | Name: BIO-1790735

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BIO-1790735 is a OGA ligand which demonstrates irreversible binding kinetics in PET measurements. BIO-1790735 is a potential radioligand for imaging and for measuring target engagement of OGA in the human brain.

Chemical Structure

BIO-1790735

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 150008

Name: BIO-1790735

CAS#: N/A

Chemical Formula: C16H21FN6OS

Exact Mass: 364.1482

Molecular Weight: 364.44

Elemental Analysis: C, 52.73; H, 5.81; F, 5.21; N, 23.06; O, 4.39; S, 8.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

BIO-1790735; BIO1790735; BIO 1790735;

IUPAC/Chemical Name

(S)-N-(5-((3-((5-fluoropyrimidin-2-yl)(methyl)amino)piperidin-1-yl)methyl)thiazol-2-yl)acetamide

InChi Key

LHGKNKNGEXTETO-ZDUSSCGKSA-N

InChi Code

1S/C16H21FN6OS/c1-11(24)21-16-20-8-14(25-16)10-23-5-3-4-13(9-23)22(2)15-18-6-12(17)7-19-15/h6-8,13H,3-5,9-10H2,1-2H3,(H,20,21,24)/t13-/m0/s1

SMILES Code

CC(NC1=NC=C(CN2C[C@@H](N(C3=NC=C(F)C=N3)C)CCC2)S1)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 364.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Nag, S.; Arakawa, R.; Datta, P.; Morén, A.; Varrone, A.; Moein, M. M.; Bolin, M.; Lin, E.; Genung, N.; Martarello, L. Synthesis and biological evaluation of a novel radioligand [11C] BIO-1790735 for detection of O-GlcNAcase (OGA) enzyme activity. Nucl. Med. Biol. 2022, 108, S26