KY-455 | CAS#178469-71-1 | ACAT Inhibitor

MedKoo Cat#: 145178 | Name: KY-455

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KY-455 is an anti-oxidative ACAT inhibitor. KY-455 inhibited rabbit intestinal, hepatic, macrophage and adrenal ACAT with IC50 values of 0.4, 0.9, 2.9 and 4.1 micromol/l, respectively. KY-455 also inhibited ex vivo peroxidation of plasma lipids 1 and 5 h after the final administration in rabbits. KY-455 is expected to prevent the progress of atherosclerosis by lowering plasma lipid levels, inhibiting both LDL-oxidation and accumulation of cholesterol in macrophages.

Chemical Structure

KY-455

CAS#178469-71-1

Theoretical Analysis

MedKoo Cat#: 145178

Name: KY-455

CAS#: 178469-71-1

Chemical Formula: C20H32N2O

Exact Mass: 316.2515

Molecular Weight: 316.49

Elemental Analysis: C, 75.90; H, 10.19; N, 8.85; O, 5.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

KY-455; KY455; KY 455;

IUPAC/Chemical Name

N-(4,6-dimethyl-1-pentylindolin-7-yl)pivalamide

InChi Key

HYEIHNVWTVQZFH-UHFFFAOYSA-N

InChi Code

1S/C20H32N2O/c1-7-8-9-11-22-12-10-16-14(2)13-15(3)17(18(16)22)21-19(23)20(4,5)6/h13H,7-12H2,1-6H3,(H,21,23)

SMILES Code

CCCCCN1CCC2=C1C(NC(=O)C(C)(C)C)=C(C)C=C2C

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 316.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Nakamura S, Kamiya S, Shirahase H, Kanda M, Yoshimi A, Tarumi T, Kurahashi K. Hypolipidemic and antioxidant activity of the novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor KY-455 in rabbits and hamsters. Arzneimittelforschung. 2004;54(2):102-8. doi: 10.1055/s-0031-1296943. PMID: 15038459. 2: Miike T, Shirahase H, Jino H, Kunishiro K, Kanda M, Kurahashi K. Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell-derived foam cells. Life Sci. 2008 Jan 2;82(1-2):79-84. doi: 10.1016/j.lfs.2007.10.011. Epub 2007 Nov 26. PMID: 18037448.