SPG-302 is a neuro-protectant with potentials to regenerate synapses and improve cognitive and motor functions in various neurodegenerative conditions. In a transgenic mouse model of Alzheimer's disease, SPG-302 treatment increased dendritic spine density and enhanced the expression of key postsynaptic proteins, leading to significant improvements in synaptic and cognitive deficits without altering amyloid or tau pathology. Similarly, in a rat model of spinal cord injury, SPG-302 administration over 14 days ameliorated electromyography deficits of the diaphragm muscle and improved functional recovery, indicating its potential to enhance motor function post-injury.
MedKoo Cat#: 145166
Name: SPG-302
CAS#: 2274723-90-7
Chemical Formula: C21H25NO5S
Exact Mass: 403.1453
Molecular Weight: 403.49
Elemental Analysis: C, 62.51; H, 6.25; N, 3.47; O, 19.83; S, 7.95
The following data is based on the product molecular weight 403.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
