DS44470011 | hypoxia-inducible factor prolyl hydroxylase inhibitor

MedKoo Cat#: 127282 | Name: DS44470011

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DS44470011 is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor for the treatment of renal anemia. DS44470011 improves the effectiveness of erythropoietin (EPO) release in cells. Oral administration of DS44470011 to cynomolgus monkeys increased plasma EPO levels.

Chemical Structure

DS44470011

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 127282

Name: DS44470011

CAS#: N/A

Chemical Formula: C21H19N3O4

Exact Mass: 377.1376

Molecular Weight: 377.40

Elemental Analysis: C, 66.83; H, 5.07; N, 11.13; O, 16.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

DS44470011; DS-44470011; DS 44470011

IUPAC/Chemical Name

(2-([1,1'-biphenyl]-4-ylmethyl)-5-hydroxy-6-methylpyrimidine-4-carbonyl)glycine

InChi Key

RNJLQAHYMHEWME-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H19N3O4/c1-13-20(27)19(21(28)22-12-18(25)26)24-17(23-13)11-14-7-9-16(10-8-14)15-5-3-2-4-6-15/h2-10,27H,11-12H2,1H3,(H,22,28)(H,25,26)

SMILES Code

CC1=C(O)C(C(NCC(O)=O)=O)=NC(CC2=CC=C(C3=CC=CC=C3)C=C2)=N1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 377.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Fukuda T, Kuribayashi T, Takano R, Sasaki K, Tsuji T, Niitsu Y, Ishii K, Hashimoto M, Baba D, Ito S, Tanaka N. Discovery of DS44470011: An oral hypoxia-inducible factor prolyl hydroxylase inhibitor for the treatment of renal anemia. Bioorg Med Chem Lett. 2024 Aug 1;108:129799. doi: 10.1016/j.bmcl.2024.129799. Epub 2024 May 15. PMID: 38754564.