MedKoo Cat#: 145157 | Name: Courmarin 355

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Courmarin 355 is a biochemical.

Chemical Structure

Courmarin 355
Courmarin 355
CAS#68975-49-5

Theoretical Analysis

MedKoo Cat#: 145157

Name: Courmarin 355

CAS#: 68975-49-5

Chemical Formula: C15H14F3NO2

Exact Mass: 297.0977

Molecular Weight: 297.28

Elemental Analysis: C, 60.61; H, 4.75; F, 19.17; N, 4.71; O, 10.76

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Courmarin 355; NSC-338969;
IUPAC/Chemical Name
9-ethyl-4-(trifluoromethyl)-6,7,8,9-tetrahydro-2H-pyrano[3,2-g]quinolin-2-one
InChi Key
FNGKJWDTEBDTNX-UHFFFAOYSA-N
InChi Code
1S/C15H14F3NO2/c1-2-19-5-3-4-9-6-10-11(15(16,17)18)7-14(20)21-13(10)8-12(9)19/h6-8H,2-5H2,1H3
SMILES Code
CCN1CCCC2=CC3=C(OC(=O)C=C3C(F)(F)F)C=C12
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 297.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dorababu A. Pharmacological report of recently designed multifunctional coumarin and coumarin-heterocycle derivatives. Arch Pharm (Weinheim). 2022 Feb;355(2):e2100345. doi: 10.1002/ardp.202100345. Epub 2021 Oct 24. PMID: 34693550. 2: Yang Q, Váňa J, Klán P. The complex photochemistry of coumarin-3-carboxylic acid in acetonitrile and methanol. Photochem Photobiol Sci. 2022 Aug;21(8):1481-1495. doi: 10.1007/s43630-022-00238-8. Epub 2022 May 17. PMID: 35578152. 3: Verbon EH, Trapet PL, Stringlis IA, Kruijs S, Bakker PAHM, Pieterse CMJ. Iron and Immunity. Annu Rev Phytopathol. 2017 Aug 4;55:355-375. doi: 10.1146/annurev- phyto-080516-035537. Epub 2017 Jun 9. PMID: 28598721. 4: Bùi NKN, Selberg S, Herodes K, Leito I. Coumarin-based derivatization reagent for LC-MS analysis of amino acids. Talanta. 2023 Jan 15;252:123730. doi: 10.1016/j.talanta.2022.123730. Epub 2022 Aug 5. PMID: 36030735. 5: Expression of Concern: Pari, L. and Rajarajeswari, N. (2011). Antioxidant role of coumarin on streptozotocin-nicotinamide-induced type 2 diabetic rats. J. Biochem. Mol. Toxicol., 25: 355-361. https://doi.org/10.1002/jbt.20395. J Biochem Mol Toxicol. 2020 Sep;34(9):e22598. doi: 10.1002/jbt.22598. Epub 2020 Aug 12. Erratum for: J Biochem Mol Toxicol. 2011 Nov-Dec;25(6):355-61. doi: 10.1002/jbt.20395. PMID: 32783297. 6: Kehrloesser D, Baumann RP, Kim HC, Hampp N. Photochemistry of coumarin- functionalized SiO2 nanoparticles. Langmuir. 2011 Apr 5;27(7):4149-55. doi: 10.1021/la200238y. Epub 2011 Mar 14. PMID: 21401069. 7: Scheul T, Wang I, Vial JC. STED-SPIM made simple. Opt Express. 2014 Dec 15;22(25):30852-64. doi: 10.1364/OE.22.030852. PMID: 25607034. 8: Ahmed EY, Abdelhafez OM, Zaafar D, Serry AM, Ahmed YH, El-Telbany RFA, Abd Elmageed ZY, Ali HI. Antitumor and multikinase inhibition activities of some synthesized coumarin and benzofuran derivatives. Arch Pharm (Weinheim). 2022 Jun;355(6):e2100327. doi: 10.1002/ardp.202100327. Epub 2022 Mar 14. PMID: 35285986. 9: Sun Y, Lv R, Wu T, Zhang X, Sun Y, Yan J, Zhang Z, Zhao D, Cheng M. Design, synthesis, and biological evaluation of coumarin analogs as novel LSD1 inhibitors. Arch Pharm (Weinheim). 2022 Feb;355(2):e2100311. doi: 10.1002/ardp.202100311. Epub 2021 Dec 4. PMID: 34862974. 10: Au N, Rettie AE. Pharmacogenomics of 4-hydroxycoumarin anticoagulants. Drug Metab Rev. 2008;40(2):355-75. doi: 10.1080/03602530801952187. PMID: 18464049. 11: Thacker PS, Newaskar V, Angeli A, Sigalapalli DK, Goud NS, Chirra H, Shaik AB, Arifuddin M, Supuran CT. Synthesis and biological evaluation of coumarin- thiazole hybrids as selective carbonic anhydrase IX and XII inhibitors. Arch Pharm (Weinheim). 2022 Dec;355(12):e2200232. doi: 10.1002/ardp.202200232. Epub 2022 Sep 19. PMID: 36122182. 12: Qian D, Zhao Y, Yang G, Huang L. Systematic Review of Chemical Constituents in the Genus Lycium (Solanaceae). Molecules. 2017 Jun 8;22(6):911. doi: 10.3390/molecules22060911. PMID: 28629116; PMCID: PMC6152755. 13: Richard EG. The Science and (Lost) Art of Psoralen Plus UVA Phototherapy. Dermatol Clin. 2020 Jan;38(1):11-23. doi: 10.1016/j.det.2019.08.002. Epub 2019 Oct 18. PMID: 31753184. 14: Zaiou M, El Amri H. Cardiovascular pharmacogenetics: a promise for genomically-guided therapy and personalized medicine. Clin Genet. 2017 Mar;91(3):355-370. doi: 10.1111/cge.12881. Epub 2016 Nov 30. PMID: 27714756. 15: Sudevan ST, Rangarajan TM, Al-Sehemi AG, Nair AS, Koyiparambath VP, Mathew B. Revealing the role of the benzyloxy pharmacophore in the design of a new class of monoamine oxidase-B inhibitors. Arch Pharm (Weinheim). 2022 Aug;355(8):e2200084. doi: 10.1002/ardp.202200084. Epub 2022 May 13. PMID: 35567313. 16: Rajarajeswari N, Pari L. Antioxidant role of coumarin on streptozotocin- nicotinamide-induced type 2 diabetic rats. J Biochem Mol Toxicol. 2011 Nov- Dec;25(6):355-61. doi: 10.1002/jbt.20395. Epub 2011 May 31. Erratum in: J Biochem Mol Toxicol. 2020 Sep;34(9):e22598. doi: 10.1002/jbt.22598. PMID: 21630391. 17: Pakbaz Z, Wun T. Role of the hemostatic system on sickle cell disease pathophysiology and potential therapeutics. Hematol Oncol Clin North Am. 2014 Apr;28(2):355-74. doi: 10.1016/j.hoc.2013.11.011. Epub 2014 Jan 18. PMID: 24589271; PMCID: PMC3984936. 18: Hart RG, Halperin JL. Do current guidelines result in overuse of warfarin anticoagulation in patients with atrial fibrillation? Ann Intern Med. 2009 Sep 1;151(5):355-6. doi: 10.7326/0003-4819-151-5-200909010-00012. PMID: 19721024. 19: Grasso M, Bagley D, Sullivan K. Pulsed dye laser lithotripsy--currently applied to urologic and biliary calculi. J Clin Laser Med Surg. 1991 Oct;9(5):355-9. doi: 10.1089/clm.1991.9.355. PMID: 10150133. 20: RUSSEK HI. CURRENT MYTHS AND REALITIES IN ANTICOAGULANT THERAPY FOR CORONARY HEART DISEASE. Med Clin North Am. 1964 Mar;48:355-70. PMID: 14149240.