MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 145153 | Name: Mehtylliberine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Methylliberine is a methoxiuric acid. Methylliberine is a caffeine metabolite present at low levels in various Coffea plants. Studies show that Methylliberine significantly improves subjective feelings of energy, concentration, motivation, and mood, but not cognitive function. Studies also show that Methylliberine also seemed to have a positive impact on sustained energy in women.

Chemical Structure

Mehtylliberine
Mehtylliberine
CAS#51168-26-4

Theoretical Analysis

MedKoo Cat#: 145153

Name: Mehtylliberine

CAS#: 51168-26-4

Chemical Formula: C9H12N4O3

Exact Mass: 224.0909

Molecular Weight: 224.22

Elemental Analysis: C, 48.21; H, 5.39; N, 24.99; O, 21.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Mehtylliberine;
IUPAC/Chemical Name
2-methoxy-1,7,9-trimethyl-7,9-dihydro-1H-purine-6,8-dione
InChi Key
ZVQXCXPGLSBNCX-UHFFFAOYSA-N
InChi Code
1S/C9H12N4O3/c1-11-5-6(12(2)9(11)15)10-8(16-4)13(3)7(5)14/h1-4H3
SMILES Code
COC1=NC2=C(N(C)C(=O)N2C)C(=O)N1C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 224.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: La Monica MB, Raub B, Malone K, Hartshorn S, Grdic J, Gustat A, Sandrock J. Methylliberine Ingestion Improves Various Indices of Affect but Not Cognitive Function in Healthy Men and Women. Nutrients. 2023 Oct 24;15(21):4509. doi: 10.3390/nu15214509. PMID: 37960163; PMCID: PMC10650428. 2: Murbach TS, Glávits R, Endres JR, Clewell AE, Hirka G, Vértesi A, Béres E, Szakonyiné IP. A Toxicological Evaluation of Methylliberine (Dynamine®). J Toxicol. 2019 Oct 27;2019:4981420. doi: 10.1155/2019/4981420. PMID: 31911801; PMCID: PMC6930730. 3: Cintineo HP, Bello ML, Chandler AJ, Cardaci TD, McFadden BA, Arent SM. Effects of caffeine, methylliberine, and theacrine on vigilance, marksmanship, and hemodynamic responses in tactical personnel: a double-blind, randomized, placebo-controlled trial. J Int Soc Sports Nutr. 2022 Aug 18;19(1):543-564. doi: 10.1080/15502783.2022.2113339. PMID: 36016763; PMCID: PMC9397462. 4: VanDusseldorp TA, Stratton MT, Bailly AR, Holmes AJ, Alesi MG, Feito Y, Mangine GT, Hester GM, Esmat TA, Barcala M, Tuggle KR, Snyder M, Modjeski AS. Safety of Short-Term Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine® in Young Adults. Nutrients. 2020 Feb 28;12(3):654. doi: 10.3390/nu12030654. PMID: 32121218; PMCID: PMC7146520. 5: Wang YH, Mondal G, Butawan M, Bloomer RJ, Yates CR. Development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for characterizing caffeine, methylliberine, and theacrine pharmacokinetics in humans. J Chromatogr B Analyt Technol Biomed Life Sci. 2020 Oct 15;1155:122278. doi: 10.1016/j.jchromb.2020.122278. Epub 2020 Aug 2. PMID: 32829142. 6: Tartar JL, Banks JB, Marang M, Pizzo F, Antonio J. A Combination of Caffeine, TeaCrine® (Theacrine), and Dynamine® (Methylliberine) Increases Cognitive Performance and Reaction Time Without Interfering With Mood in Adult Male Egamers. Cureus. 2021 Dec 20;13(12):e20534. doi: 10.7759/cureus.20534. PMID: 35103121; PMCID: PMC8768451. 7: Petermann JB, Baumann TW. Metabolic Relations between Methylxanthines and Methyluric Acids in Coffea L. Plant Physiol. 1983 Dec;73(4):961-4. doi: 10.1104/pp.73.4.961. PMID: 16663351; PMCID: PMC1066588.

View History

TR100

TR100

Featured