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MedKoo Cat#: 145146 | Name: PEPA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PEPA is an allosteric potentiator of AMPA receptors that preferentially affects flop splice variants. PEPA provides a novel framework for extending the high-throughput of 1 H-NMR metabolic profiling to stable isotope tracing in metabolomics.

Chemical Structure

PEPA
PEPA
CAS#141286-78-4

Theoretical Analysis

MedKoo Cat#: 145146

Name: PEPA

CAS#: 141286-78-4

Chemical Formula: C16H16F2N2O4S2

Exact Mass: 402.0520

Molecular Weight: 402.43

Elemental Analysis: C, 47.75; H, 4.01; F, 9.44; N, 6.96; O, 15.90; S, 15.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PEPA;
IUPAC/Chemical Name
2-(2,6-difluoro-4-((2-(phenylsulfonamido)ethyl)thio)phenoxy)acetamide
InChi Key
GTACSIONMHMRPD-UHFFFAOYSA-N
InChi Code
1S/C16H16F2N2O4S2/c17-13-8-11(9-14(18)16(13)24-10-15(19)21)25-7-6-20-26(22,23)12-4-2-1-3-5-12/h1-5,8-9,20H,6-7,10H2,(H2,19,21)
SMILES Code
NC(=O)COC1=C(F)C=C(SCCNS(=O)(=O)C2=CC=CC=C2)C=C1F
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 402.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Movilli E. A comment on "Early use of a PEPA (polyester polymer alloy) dialyzer for light chain removal and for the recovery from myeloma cast nephropathy: A case report". Hemodial Int. 2020 Apr;24(2):261. doi: 10.1111/hdi.12816. Epub 2020 Feb 12. PMID: 32052559. 2: Klinkmann H, Vienken J. Membranes for dialysis. Cas Lek Cesk. 1994 May 30;133(11):323-9. PMID: 8004659. 3: Donati G, Zappulo F, Croci Chiocchini AL, Comai G, Zamagni E, La Manna G. Early use of PEPA dialyzer for light chains removal and for the recovery from myeloma cast nephropathy: A case report. Hemodial Int. 2019 Jul;23(3):E97-E99. doi: 10.1111/hdi.12733. Epub 2019 Feb 21. PMID: 30791209. 4: Ki MR, Lee JH, Yun SK, Choi KM, Hwang SY. Roles of the Peptide Transport Systems and Aminopeptidase PepA in Peptide Assimilation by Helicobacter pylori. J Microbiol Biotechnol. 2015 Oct;25(10):1629-33. doi: 10.4014/jmb.1505.05099. PMID: 26215272. 5: Minh PN, Devroede N, Massant J, Maes D, Charlier D. Insights into the architecture and stoichiometry of Escherichia coli PepA*DNA complexes involved in transcriptional control and site-specific DNA recombination by atomic force microscopy. Nucleic Acids Res. 2009 Apr;37(5):1463-76. doi: 10.1093/nar/gkn1078. Epub 2009 Jan 9. PMID: 19136463; PMCID: PMC2655662. 6: Nakagawa T, Iino M, Sekiguchi M, Wada K, Ozawa S. Potentiating effects of 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyaceta mide (PEPA) on excitatory synaptic transmission in dentate granule cells. Neurosci Res. 1999 Dec 1;35(3):217-23. doi: 10.1016/s0168-0102(99)00087-5. PMID: 10605945. 7: Nguyen Le Minh P, Nadal M, Charlier D. The trigger enzyme PepA (aminopeptidase A) of Escherichia coli, a transcriptional repressor that generates positive supercoiling. FEBS Lett. 2016 Jun;590(12):1816-25. doi: 10.1002/1873-3468.12224. Epub 2016 Jun 7. PMID: 27213286. 8: Lutfullah G, Azhar N, Amin F, Khan Z, Azim MK, Shouqat K, Noor S, Ali R. Structural bioinformatics of Vibrio cholerae aminopeptidase A (PepA) monomer. Protein Pept Lett. 2009;16(1):36-45. doi: 10.2174/092986609787049484. PMID: 19149671. 9: Igoshi T, Tomisawa N, Hori Y, Jinbo Y. Polyester polymer alloy as a high- performance membrane. Contrib Nephrol. 2011;173:148-155. doi: 10.1159/000329053. Epub 2011 Aug 8. PMID: 21865787. 10: López-Berges MS, Pinar M, Abenza JF, Arst HN Jr, Peñalva MA. The Aspergillus nidulans syntaxin PepA(Pep12) is regulated by two Sec1/Munc-18 proteins to mediate fusion events at early endosomes, late endosomes and vacuoles. Mol Microbiol. 2016 Jan;99(1):199-216. doi: 10.1111/mmi.13226. Epub 2015 Oct 26. PMID: 26395371. 11: Gomi K, Arikawa K, Kamiya N, Kitamoto K, Kumagai C. Cloning and nucleotide sequence of the acid protease-encoding gene (pepA) from Aspergillus oryzae. Biosci Biotechnol Biochem. 1993 Jul;57(7):1095-100. doi: 10.1271/bbb.57.1095. PMID: 7763981. 12: Kim D, San BH, Moh SH, Park H, Kim DY, Lee S, Kim KK. Structural basis for the substrate specificity of PepA from Streptococcus pneumoniae, a dodecameric tetrahedral protease. Biochem Biophys Res Commun. 2010 Jan 1;391(1):431-6. doi: 10.1016/j.bbrc.2009.11.075. Epub 2009 Nov 13. PMID: 19914209. 13: Sekiguchi M, Yamada K, Jin J, Hachitanda M, Murata Y, Namura S, Kamichi S, Kimura I, Wada K. The AMPA receptor allosteric potentiator PEPA ameliorates post-ischemic memory impairment. Neuroreport. 2001 Sep 17;12(13):2947-50. doi: 10.1097/00001756-200109170-00038. PMID: 11588608. 14: Zushida K, Sakurai M, Wada K, Sekiguchi M. Facilitation of extinction learning for contextual fear memory by PEPA: a potentiator of AMPA receptors. J Neurosci. 2007 Jan 3;27(1):158-66. doi: 10.1523/JNEUROSCI.3842-06.2007. PMID: 17202483; PMCID: PMC6672292. 15: Charlier D, Hassanzadeh G, Kholti A, Gigot D, Piérard A, Glansdorff N. carP, involved in pyrimidine regulation of the Escherichia coli carbamoylphosphate synthetase operon encodes a sequence-specific DNA-binding protein identical to XerB and PepA, also required for resolution of ColEI multimers. J Mol Biol. 1995 Jul 21;250(4):392-406. doi: 10.1006/jmbi.1995.0385. PMID: 7616564. 16: Paul S, Summers D. ArgR and PepA, accessory proteins for XerCD-mediated resolution of ColE1 dimers, are also required for stable maintenance of the P1 prophage. Plasmid. 2004 Jul;52(1):63-8. doi: 10.1016/j.plasmid.2004.04.003. PMID: 15212893. 17: Pepa GD, Brandi ML. Microelements for bone boost: the last but not the least. Clin Cases Miner Bone Metab. 2016 Sep-Dec;13(3):181-185. doi: 10.11138/ccmbm/2016.13.3.181. Epub 2017 Feb 10. PMID: 28228778; PMCID: PMC5318168. 18: Vinaixa M, Rodríguez MA, Aivio S, Capellades J, Gómez J, Canyellas N, Stracker TH, Yanes O. Positional Enrichment by Proton Analysis (PEPA): A One- Dimensional 1 H-NMR Approach for 13 C Stable Isotope Tracer Studies in Metabolomics. Angew Chem Int Ed Engl. 2017 Mar 20;56(13):3531-3535. doi: 10.1002/anie.201611347. Epub 2017 Feb 21. PMID: 28220994; PMCID: PMC5363230. 19: Hebert AM, Talarico S, Yang D, Durmaz R, Marrs CF, Zhang L, Foxman B, Yang Z. DNA polymorphisms in the pepA and PPE18 genes among clinical strains of Mycobacterium tuberculosis: implications for vaccine efficacy. Infect Immun. 2007 Dec;75(12):5798-805. doi: 10.1128/IAI.00335-07. Epub 2007 Sep 24. PMID: 17893137; PMCID: PMC2168324. 20: Kitano H, Kataoka K, Furukawa K, Hara S. Specific expression and temperature-dependent expression of the acid protease-encoding gene (pepA) in Aspergillus oryzae in solid-state culture (Rice-Koji). J Biosci Bioeng. 2002;93(6):563-7. doi: 10.1016/s1389-1723(02)80238-9. PMID: 16233250.