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MedKoo Cat#: 145136 | Name: LY-266097

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY-266097 is a selective 5-HT2BR antagonists. LY-266097 reduces tactile allodynia, indicating a potential therapeutic effect in alleviating nerve injury-induced pain. LY-266097 attenuates the upregulation of 5-HT2B receptors in the dorsal root ganglia and spinal cord following nerve injury. Studies show that it has a potential role in the development of neuropathic pain pathways.

Chemical Structure

LY-266097
LY-266097
CAS#208591-60-0

Theoretical Analysis

MedKoo Cat#: 145136

Name: LY-266097

CAS#: 208591-60-0

Chemical Formula: C21H23ClN2O2

Exact Mass: 370.1448

Molecular Weight: 370.88

Elemental Analysis: C, 68.01; H, 6.25; Cl, 9.56; N, 7.55; O, 8.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LY-266097; LY 266097; LY 266097; LY-266,097;
IUPAC/Chemical Name
1-(2-chloro-3,4-dimethoxybenzyl)-6-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
InChi Key
NJLHHCITDFZZSE-UHFFFAOYSA-N
InChi Code
1S/C21H23ClN2O2/c1-12-4-6-16-15(10-12)14-8-9-23-17(20(14)24-16)11-13-5-7-18(25-2)21(26-3)19(13)22/h4-7,10,17,23-24H,8-9,11H2,1-3H3
SMILES Code
COC1=C(OC)C(Cl)=C(CC2NCCC3=C2NC4=C3C=C(C)C=C4)C=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 370.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Devroye C, Cathala A, Di Marco B, Caraci F, Drago F, Piazza PV, Spampinato U. Central serotonin(2B) receptor blockade inhibits cocaine-induced hyperlocomotion independently of changes of subcortical dopamine outflow. Neuropharmacology. 2015 Oct;97:329-37. doi: 10.1016/j.neuropharm.2015.06.012. Epub 2015 Jun 25. PMID: 26116760. 2: Auclair AL, Cathala A, Sarrazin F, Depoortère R, Piazza PV, Newman-Tancredi A, Spampinato U. The central serotonin 2B receptor: a new pharmacological target to modulate the mesoaccumbens dopaminergic pathway activity. J Neurochem. 2010 Sep 1;114(5):1323-32. doi: 10.1111/j.1471-4159.2010.06848.x. Epub 2010 Jun 7. PMID: 20534001. 3: Devroye C, Cathala A, Haddjeri N, Rovera R, Vallée M, Drago F, Piazza PV, Spampinato U. Differential control of dopamine ascending pathways by serotonin2B receptor antagonists: New opportunities for the treatment of schizophrenia. Neuropharmacology. 2016 Oct;109:59-68. doi: 10.1016/j.neuropharm.2016.05.024. Epub 2016 May 31. PMID: 27260325. 4: Pineda-Farias JB, Velázquez-Lagunas I, Barragán-Iglesias P, Cervantes-Durán C, Granados-Soto V. 5-HT2B Receptor Antagonists Reduce Nerve Injury- Induced Tactile Allodynia and Expression of 5-HT2B Receptors. Drug Dev Res. 2015 Feb;76(1):31-39. doi: 10.1002/ddr.21238. Epub 2015 Jan 25. PMID: 25620128. 5: Gleason SD, Lucaites VL, Shannon HE, Nelson DL, Leander JD. m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT(2C) receptors but not 5-HT(2A) or 5-HT(2B) receptors. Behav Pharmacol. 2001 Dec;12(8):613-20. doi: 10.1097/00008877-200112000-00005. PMID: 11856898. 6: Cathala A, Devroye C, Robert É, Vallée M, Revest JM, Artigas F, Spampinato U. Serotonin2B receptor blockade in the rat dorsal raphe nucleus suppresses cocaine-induced hyperlocomotion through an opposite control of mesocortical and mesoaccumbens dopamine pathways. Neuropharmacology. 2020 Dec 1;180:108309. doi: 10.1016/j.neuropharm.2020.108309. Epub 2020 Sep 18. PMID: 32956675. 7: Chenu F, Shim S, El Mansari M, Blier P. Role of melatonin, serotonin 2B, and serotonin 2C receptors in modulating the firing activity of rat dopamine neurons. J Psychopharmacol. 2014 Feb;28(2):162-7. doi: 10.1177/0269881113510071. Epub 2013 Nov 4. PMID: 24189440. 8: M'Dahoma S, Poitevin M, Dabala E, Payan H, Gabriel C, Mocaër E, Bourgoin S, Hamon M. α2- and β2-Adrenoreceptor-Mediated Efficacy of the Atypical Antidepressant Agomelatine Combined With Gabapentin to Suppress Allodynia in Neuropathic Rats With Ligated Infraorbital or Sciatic Nerve. Front Pharmacol. 2018 Jun 7;9:587. doi: 10.3389/fphar.2018.00587. PMID: 29930510; PMCID: PMC5999781.

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