MedKoo Cat#: 127238 | Name: PSB-KK1445
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

PSB-KK1445 is a Potent, Selective Agonist for the Cannabinoid-like Orphan G Protein-Coupled Receptor GPR18. PSB-KK1445 showed EC50 45.4 nM.

Chemical Structure

PSB-KK1445
PSB-KK1445
CAS#885896-54-8

Theoretical Analysis

MedKoo Cat#: 127238

Name: PSB-KK1445

CAS#: 885896-54-8

Chemical Formula: C24H23FN6O2

Exact Mass: 446.1867

Molecular Weight: 446.49

Elemental Analysis: C, 64.56; H, 5.19; F, 4.26; N, 18.82; O, 7.17

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 550.00 2 Weeks
25mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
PSB-KK1445; PSBKK1445; PSB KK1445
IUPAC/Chemical Name
8-((2-(1H-indol-3-yl)ethyl)amino)-7-(4-fluorobenzyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
InChi Key
JMZXYZSTEKMPDV-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H23FN6O2/c1-29-21-20(22(32)30(2)24(29)33)31(14-15-7-9-17(25)10-8-15)23(28-21)26-12-11-16-13-27-19-6-4-3-5-18(16)19/h3-10,13,27H,11-12,14H2,1-2H3,(H,26,28)
SMILES Code
O=C(N1C)N(C)C2=C(N(CC3=CC=C(F)C=C3)C(NCCC4=CNC5=C4C=CC=C5)=N2)C1=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 446.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Mahardhika AB, Załuski M, Schoeder CT, Boshta NM, Schabikowski J, Perri F, Łażewska D, Neumann A, Kremers S, Oneto A, Ressemann A, Latacz G, Namasivayam V, Kieć-Kononowicz K, Müller CE. Potent, Selective Agonists for the Cannabinoid-like Orphan G Protein-Coupled Receptor GPR18: A Promising Drug Target for Cancer and Immunity. J Med Chem. 2024 Jun 17. doi: 10.1021/acs.jmedchem.3c02423. Epub ahead of print. PMID: 38885438.