D-159404 is an allosteric inhibitor. D-159404 demonstrates superior inhibition of full-length PDE 4D3 compared to a truncated form, and exhibited high cellular activity, distinguishing it from competitive inhibitors like roflumilast and cilomilast. These findings suggest that D-159404 and related compounds could offer valuable insights into PDE 4 pharmacology and serve as potent candidates for further research in treating conditions influenced by cAMP signaling.
MedKoo Cat#: 145113
Name: D-159404
CAS#: 1158221-32-9
Chemical Formula: C21H18ClFN2O2
Exact Mass: 384.1041
Molecular Weight: 384.84
Elemental Analysis: C, 65.54; H, 4.71; Cl, 9.21; F, 4.94; N, 7.28; O, 8.31
The following data is based on the product molecular weight 384.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
