KA-2507 is a potent and selective inhibitor of HDAC6 (biochemical IC50 = 2.5 nmol/L). KA2507 demonstrates antitumor efficacy and immune modulatory effects in preclinical models of melanoma and colorectal cancer. KA2507 shows selective HDAC6 target engagement, good tolerability with no dose-limiting toxicity observed, and prolonged disease stabilization in a subset of patients, supporting further clinical investigations, potentially in combination with other immuno-oncology drugs.
MedKoo Cat#: 145100
Name: KA-2507
CAS#: 1636894-46-6
Chemical Formula: C16H14N6O2
Exact Mass: 322.1178
Molecular Weight: 322.33
Elemental Analysis: C, 59.62; H, 4.38; N, 26.07; O, 9.93
The following data is based on the product molecular weight 322.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
