WSD0628 is a novel and potent Ataxia telangiectasia mutated inhibitor. WSD0628 is orally bioavailable and CNS penetrant, with unbound partitioning in CNS (i.e., Kpuu) between 0.15 and 0.3. WSD0628 has favorable pharmacokinetic properties and potential for further exploration to determine the PK-PD-efficacy relationship in CNS tumors. Studies show that WSD0628 has potential for further exploration for use as a radiosensitizer in the treatment of brain tumors.
MedKoo Cat#: 145096
Name: WSD0628
CAS#: 2765448-96-0
Chemical Formula: C23H23F2N5O2
Exact Mass: 439.1820
Molecular Weight: 439.47
Elemental Analysis: C, 62.86; H, 5.28; F, 8.65; N, 15.94; O, 7.28
The following data is based on the product molecular weight 439.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
