Rongliflozin | CAS#2035989-50-3 | Inhibitor

MedKoo Cat#: 145080 | Name: Rongliflozin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rongliflozin is a novel selective inhibitor of sodium-glucose co-transporter-2, in people with type 2 diabetes mellitus. Systemic exposure to rongliflozin were accompanied by dose-related decreases in serum glucose values in people with T2DM.

Chemical Structure

Rongliflozin

CAS#2035989-50-3

Theoretical Analysis

MedKoo Cat#: 145080

Name: Rongliflozin

CAS#: 2035989-50-3

Chemical Formula: C23H27ClO7

Exact Mass: 450.1445

Molecular Weight: 450.91

Elemental Analysis: C, 61.27; H, 6.04; Cl, 7.86; O, 24.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Rongliflozin; Olorigliflozinum; Olorigliflozin

IUPAC/Chemical Name

(1R,2S,3S,4R,5S)-5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1-((R)-1-hydroxyethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol

InChi Key

KODGTDKHPNYCCJ-YWRILDCISA-N

InChi Code

1S/C23H27ClO7/c1-3-29-17-7-4-14(5-8-17)10-15-11-16(6-9-18(15)24)23-21(28)19(26)20(27)22(31-23,12-30-23)13(2)25/h4-9,11,13,19-21,25-28H,3,10,12H2,1-2H3/t13-,19+,20+,21-,22-,23+/m1/s1

SMILES Code

CCOC1=CC=C(CC2=C(Cl)C=CC(=C2)[C@]34OC[C@@](O3)([C@@H](C)O)[C@@H](O)[C@H](O)[C@H]4O)C=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 450.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhang H, Zhu X, Li X, Chen H, Wu M, Li C, Liu J, Liu C, Zhang Y, Ding Y. Pharmacokinetics and pharmacodynamics of rongliflozin, a novel selective inhibitor of sodium-glucose co-transporter-2, in people with type 2 diabetes mellitus. Diabetes Obes Metab. 2020 Feb;22(2):191-202. doi: 10.1111/dom.13887. Epub 2019 Nov 5. PMID: 31588657. 2: Zhang H, Liu J, Zhu X, Li X, Chen H, Wu M, Li C, Ding Y. A Phase I Study on the Pharmacokinetics and Pharmacodynamics of DJT1116PG, a Novel Selective Inhibitor of Sodium-glucose Cotransporter Type 2, in Healthy Individuals at Steady State. Clin Ther. 2020 May;42(5):892-905.e3. doi: 10.1016/j.clinthera.2020.03.007. Epub 2020 Apr 4. PMID: 32265061.