C18-PAF | CAS#74389-69-8 | Phospholipid

MedKoo Cat#: 145071 | Name: C18-PAF

Description:

WARNING: This product is for research use only, not for human or veterinary use.

C18-PAF is a naturally occurring phospholipid. C18-PAF induces caspase-independent neuronal death in PAF receptor-deficient neurons. The sn-1 fatty acid is significant in modulating PAF-induced apoptosis and neuroprotection, whether mediated by PAF receptor signaling or not. C18-PAF constricts both upstream and venous segments of the pulmonary circulation.

Chemical Structure

C18-PAF

CAS#74389-69-8

Theoretical Analysis

MedKoo Cat#: 145071

Name: C18-PAF

CAS#: 74389-69-8

Chemical Formula: C28H58NO7P

Exact Mass: 551.3951

Molecular Weight: 551.75

Elemental Analysis: C, 60.95; H, 10.60; N, 2.54; O, 20.30; P, 5.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

C18-PAF; C18PAF; C18 PAF; PAF (C18); Ro-14-8161; Ro148161; Ro 14 8161; Ro14-8161; Ro-148161; C18-PAF-acether;

IUPAC/Chemical Name

(R)-2-acetoxy-3-(octadecyloxy)propyl (2-(trimethylammonio)ethyl) phosphate

InChi Key

ZXCIEWBDUAPBJF-MUUNZHRXSA-N

InChi Code

1S/C28H58NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-33-25-28(36-27(2)30)26-35-37(31,32)34-24-22-29(3,4)5/h28H,6-26H2,1-5H3/t28-/m1/s1

SMILES Code

CCCCCCCCCCCCCCCCCCOC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(C)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 551.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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FEBS Lett. 1980 Jul 28;116(2):161-4. doi: 10.1016/0014-5793(80)80633-8. PMID: 7409144. 16: Kudolo GB, Yang YQ, Chen DB, Jones MA, Harper MJ. Differential metabolism of exogenous platelet-activating factor by glandular epithelial and stromal cells of rabbit endometrium. J Reprod Fertil. 1995 Nov;105(2):315-24. doi: 10.1530/jrf.0.1050315. PMID: 8568777. 17: Wissner A, Sum PE, Schaub RE, Kohler CA, Goldstein BM. Analogues of platelet activating factor (PAF). 1. Some modifications of the alkoxy chain. J Med Chem. 1984 Sep;27(9):1174-81. doi: 10.1021/jm00375a016. PMID: 6471071. 18: Balsa D, Merlos M, Giral M, Ferrando R, García-Rafanell J, Forn J. Characterization of [3H]apafant binding to PAF receptor on rabbit platelet membranes: a comparison of a microplate filtration system and a standard method. J Pharmacol Toxicol Methods. 1996 Sep;36(1):53-62. doi: 10.1016/1056-8719(96)00074-3. 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