Synonym
WJ-39; WJ39; WJ 39
IUPAC/Chemical Name
potassium 2-(3-(2,3-dichlorobenzyl)-6-methoxy-4-oxoquinolin-1(4H)-yl)acetate
InChi Key
KOVHOMQLMHEHRB-UHFFFAOYSA-M
InChi Code
InChI=1S/C19H15Cl2NO4.K/c1-26-13-5-6-16-14(8-13)19(25)12(9-22(16)10-17(23)24)7-11-3-2-4-15(20)18(11)21;/h2-6,8-9H,7,10H2,1H3,(H,23,24);/q;+1/p-1
SMILES Code
COC1=CC=C(N(CC(O[K])=O)C=C(CC2=CC=CC(Cl)=C2Cl)C3=O)C3=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
430.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Zhou X, Liu Z, Ying K, Wang H, Liu P, Ji X, Chi T, Zou L, Wang S, He Z.
WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic
Nephropathy by Activating Nrf2 Signaling. Oxid Med Cell Longev. 2020 May
30;2020:7950457. doi: 10.1155/2020/7950457. PMID: 32566101; PMCID: PMC7277034.
2: Yang L, Xu L, Hao X, Song Z, Zhang X, Liu P, Wang S, He Z, Zou L. An aldose
reductase inhibitor, WJ-39, ameliorates renal tubular injury in diabetic
nephropathy by activating PINK1/Parkin signaling. Eur J Pharmacol. 2024 Mar
15;967:176376. doi: 10.1016/j.ejphar.2024.176376. Epub 2024 Feb 8. PMID:
38336014.
