MedKoo Cat#: 145047 | Name: Cyrtominetin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cyrtominetin is an inhibitor of α-hemolysin. Cyrtominetin binds directly to α-hemolysin, restraining the conformation of its critical "Loop" region, thus hindering its lysis activity through a novel mechanism. Cyrtominetin is a potential therapeutic agent against α-HL-mediated pathogenicity.

Chemical Structure

Cyrtominetin
Cyrtominetin
CAS#519-55-1

Theoretical Analysis

MedKoo Cat#: 145047

Name: Cyrtominetin

CAS#: 519-55-1

Chemical Formula: C17H16O6

Exact Mass: 316.0947

Molecular Weight: 316.31

Elemental Analysis: C, 64.55; H, 5.10; O, 30.35

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Cyrtominetin;
IUPAC/Chemical Name
(S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6,8-dimethylchroman-4-one
InChi Key
AESMRHCYHARBLU-ZDUSSCGKSA-N
InChi Code
1S/C17H16O6/c1-7-15(21)8(2)17-14(16(7)22)12(20)6-13(23-17)9-3-4-10(18)11(19)5-9/h3-5,13,18-19,21-22H,6H2,1-2H3/t13-/m0/s1
SMILES Code
CC1=C(O)C(C)=C2O[C@@H](CC(=O)C2=C1O)C3=CC(O)=C(O)C=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 316.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Niu X, Qiu J, Wang X, Gao X, Dong J, Wang J, Li H, Zhang Y, Dai X, Lu C, Deng X. Molecular insight into the inhibition mechanism of cyrtominetin to α-hemolysin by molecular dynamics simulation. Eur J Med Chem. 2013 Apr;62:320-8. doi: 10.1016/j.ejmech.2013.01.008. Epub 2013 Jan 14. PMID: 23376250. 2: KISHIMOTO Y. Pharmaceutical studies on ferns. XI. Flavonoids of Cyrtomium species. (3). Constitution of cyrtominetin and cyrtopterinetin. Pharm Bull. 1956 Feb;4(1):24-8. doi: 10.1248/cpb1953.4.24. PMID: 13335451.