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MedKoo Cat#: 145041 | Name: TPI-1020

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TPI-1020 is a novel anti-inflammatory corticosteroid and nitric oxide (NO) donor derived from budesonide. TPI 1020 demonstrates concentration-dependent bronchodilation, which is mediated through cGMP-dependent pathways via released NO. Studies show that TPI 1020, with its combined corticosteroid and NO-releasing activities, could be beneficial in treating acute bronchoconstriction episodes in asthma and may potentially reduce the required doses of inhaled beta(2)-adrenoceptor agonists.

Chemical Structure

TPI-1020
TPI-1020
CAS#571186-52-2

Theoretical Analysis

MedKoo Cat#: 145041

Name: TPI-1020

CAS#: 571186-52-2

Chemical Formula: C33H39NO10

Exact Mass: 609.2574

Molecular Weight: 609.67

Elemental Analysis: C, 65.01; H, 6.45; N, 2.30; O, 26.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
TPI-1020; TPI 1020; TPI1020; NCX-1020; NCX 1020;
IUPAC/Chemical Name
2-((6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-7-hydroxy-6a,8a-dimethyl-4-oxo-10-propyl-1,2,4,6a,6b,7,8,8a,11a,12,12a,12b-dodecahydro-8bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoethyl 4-((nitrooxy)methyl)benzoate
InChi Key
SYBXBIHWNMPDPT-PBCNJCODSA-N
InChi Code
1S/C33H39NO10/c1-4-5-28-43-27-15-24-23-11-10-21-14-22(35)12-13-31(21,2)29(23)25(36)16-32(24,3)33(27,44-28)26(37)18-41-30(38)20-8-6-19(7-9-20)17-42-34(39)40/h6-9,12-14,23-25,27-29,36H,4-5,10-11,15-18H2,1-3H3/t23-,24-,25-,27+,28?,29+,31-,32-,33+/m0/s1
SMILES Code
[H][C@@]12C[C@@]3([H])[C@]4([H])CCC5=CC(=O)C=C[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]1(OC(CCC)O2)C(=O)COC(=O)C6=CC=C(CO[N+]([O-])=O)C=C6
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 609.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Turner DL, Ferrari N, Ford WR, Kidd EJ, Paquet L, Renzi P, Broadley KJ. TPI 1020, a novel anti-inflammatory, nitric oxide donating compound, potentiates the bronchodilator effects of salbutamol in conscious guinea-pigs. Eur J Pharmacol. 2010 Sep 1;641(2-3):213-9. doi: 10.1016/j.ejphar.2010.05.025. Epub 2010 Jun 8. PMID: 20639142. 2: Boulet LP, Lemière C, Gauvreau G, Olivenstein R, Lougheed D, Paradis B, O'Byrne P, Pageau R, Renzi PM. Safety, pharmacodynamics and pharmacokinetics of TPI 1020 in smokers with asthma. Respir Med. 2009 Aug;103(8):1159-66. doi: 10.1016/j.rmed.2009.02.011. Epub 2009 Mar 16. PMID: 19286361. 3: Turner Dl, Ferrari N, Ford WR, Kidd EJ, Nevin B, Paquet L, Renzi P, Broadley KJ. Bronchoprotection in conscious guinea pigs by budesonide and the NO-donating analogue, TPI 1020, alone and combined with tiotropium or formoterol. Br J Pharmacol. 2012 Oct;167(3):515-26. doi: 10.1111/j.1476-5381.2012.02016.x. PMID: 22563753; PMCID: PMC3449257. 4: Nevin BJ, Broadley KJ. Comparative effects of inhaled budesonide and the NO- donating budesonide derivative, NCX 1020, against leukocyte influx and airway hyperreactivity following lipopolysaccharide challenge. Pulm Pharmacol Ther. 2004;17(4):219-32. doi: 10.1016/j.pupt.2004.04.002. PMID: 15219267.