HH0043 is a Potent SOS1 Inhibitor (IC50 = 5.8 nM). HH0043 displayed potent activities in both biochemical and cellular assays and favorable pharmacokinetic profiles. Oral administration of HH0043 resulted in a significant tumor inhibitory effect in a subcutaneous KRASG12C-mutated NCIH358 (human lung cancer cell line) xenograft mouse model, and the tumor inhibitory effect of HH0043 was superior to that of BI-3406 at the same dose (total growth inhibition, TGI: 76% vs 49%).
MedKoo Cat#: 127146
Name: HH0043
CAS#: N/A
Chemical Formula: C23H24F3N5O
Exact Mass: 443.1933
Molecular Weight: 443.47
Elemental Analysis: C, 62.29; H, 5.46; F, 12.85; N, 15.79; O, 3.61
The following data is based on the product molecular weight 443.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
