Salirasib | CAS#162520-00-5 | Antineoplastic agent

MedKoo Cat#: 202551 | Name: Salirasib

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Salirasib is a salicylic acid derivative with potential antineoplastic activity. Salirasib dislodges all Ras isoforms from their membrane-anchoring sites, thereby preventing activation of RAS signaling cascades that mediated cell proliferation, differentiation, and senescence. RAS signaling is believed to be abnormally activated in one-third of human cancers, including cancers of the pancreas, colon, lung and breast.

Chemical Structure

Salirasib

CAS#162520-00-5

Theoretical Analysis

MedKoo Cat#: 202551

Name: Salirasib

CAS#: 162520-00-5

Chemical Formula: C22H30O2S

Exact Mass: 358.1967

Molecular Weight: 358.54

Elemental Analysis: C, 73.70; H, 8.43; O, 8.92; S, 8.94

Price and Availability

Size	Price	Availability
100mg	USD 450.00	2 Weeks
200mg	USD 850.00	2 Weeks
500mg	USD 1,650.00	2 Weeks
1g	USD 2,450.00	2 Weeks
2g	USD 3,850.00	2 Weeks
5g	USD 4,950.00	2 Weeks

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Related CAS #

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Synonym

Salirasib; Farnesylthiosalicylic acid; S-Farnesylthiosalicylic acid; FTS.

IUPAC/Chemical Name

2-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)benzoic acid

InChi Key

WUILNKCFCLNXOK-CFBAGHHKSA-N

InChi Code

InChI=1S/C22H30O2S/c1-17(2)9-7-10-18(3)11-8-12-19(4)15-16-25-21-14-6-5-13-20(21)22(23)24/h5-6,9,11,13-15H,7-8,10,12,16H2,1-4H3,(H,23,24)/b18-11+,19-15+

SMILES Code

O=C(O)C1=CC=CC=C1SC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not soluble in water.

Shelf Life

>5 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Salirasib binds to a cell membrane anchor protein thereby selectively blocking a cascade of biochemical signals known as the Ras signaling pathway. The Ras pathway plays an important role in tumor growth and is believed to be abnormally activated in one-third of human cancers, including cancers of the pancreas, colon, lung and breast. Up to 90% of human pancreatic cancers are driven by aberrant oncogenic Ras signaling. For detail please see Concordia Pharmaceutical's website

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 358.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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