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MedKoo Cat#: 145014 | Name: DS-4574

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DS-4574 is a peptidoleukotriene antagonist with mast cell stabilizing activity. DS-4574 is useful for peptic ulcer therapy, as well as for the therapy of various allergic diseases, including asthma. Orally administered DS-4574 is able to inhibit bronchoconstriction mediated by intravenous administration of LTC4 and E4.

Chemical Structure

DS-4574
DS-4574
CAS#118314-35-5

Theoretical Analysis

MedKoo Cat#: 145014

Name: DS-4574

CAS#: 118314-35-5

Chemical Formula: C13H16N6OS

Exact Mass: 304.1106

Molecular Weight: 304.37

Elemental Analysis: C, 51.30; H, 5.30; N, 27.61; O, 5.26; S, 10.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
DS-4574; DS 4574; DS4574; D-S4574;
IUPAC/Chemical Name
6-(2-cyclohexylethyl)-[1,3,4]thiadiazolo[3,2-a][1,2,3]triazolo[4,5-d]pyrimidin-9(1H)-one
InChi Key
ASIFEXZWAKYMRM-UHFFFAOYSA-N
InChi Code
1S/C13H16N6OS/c20-12-10-11(16-18-15-10)14-13-19(12)17-9(21-13)7-6-8-4-2-1-3-5-8/h8H,1-7H2,(H,15,16,18)
SMILES Code
O=C1N2N=C(CCC3CCCCC3)SC2=NC4=C1NN=N4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 304.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tabuchi Y, Kurebayashi Y. Effect of DS-4574, a novel peptidoleukotriene antagonist with mast cell stabilizing action, on acute gastric lesions and gastric secretion in rats. Jpn J Pharmacol. 1992 Dec;60(4):335-40. doi: 10.1254/jjp.60.335. PMID: 1287268. 2: Aibara S, Mori M, Iwamoto T, Chiba T, Tsukada W. Antagonistic action of DS-4574 against leukotrienes in guinea-pig smooth muscle. Arch Int Pharmacodyn Ther. 1991 Nov-Dec;314:147-59. PMID: 1668601. 3: Aibara S, Mori M, Iwamoto T, Tsubokawa M, Takamori H, Tsukada W. Effects of DS-4574, a new orally active antiallergic agent, in experimental allergic and inflammatory models. Jpn J Pharmacol. 1993 Apr;61(4):267-76. doi: 10.1254/jjp.61.267. PMID: 8320873. 4: Aibara S, Mori M, Tsukada W. Inhibitory effect of DS-4574 on leukotriene- or antigen-induced bronchoconstriction in guinea pigs. Int Arch Allergy Immunol. 1993;100(3):268-73. doi: 10.1159/000236423. PMID: 7680929. 5: Tabuchi Y, Furuhama K. Inhibitory effect of DS-4574, a mast cell stabilizer with peptidoleukotriene receptor antagonism, on gastric acid secretion in rats. Eur J Pharmacol. 1994 Apr 1;255(1-3):229-34. doi: 10.1016/0014-2999(94)90102-3. PMID: 8026547. 6: Yamashika Y, Tabuchi Y, Kokue E. Antisecretory effect of DS-4574, a mast cell stabilizer with peptidoleukotriene antagonism, on gastric acid secretion in the pig. Agents Actions. 1994 Mar;41(1-2):17-20. doi: 10.1007/BF01986387. PMID: 8079817. 7: Murayama N, Nakaoka M, Nomura H, Hakusui H. Radioimmunoassay for DS-4574, an antiallergic agent: development, evaluation, and application to human plasma samples. J Pharm Sci. 1994 Nov;83(11):1574-7. doi: 10.1002/jps.2600831111. PMID: 7891277. 8: Tabuchi Y, Kawarabayashi K, Furuhama K. Inhibitory effect of DS-4574, a peptidoleukotriene antagonist with mast cell stabilizing action, on compound 48/80-induced gastric mucosal lesions in rats. Agents Actions. 1994 Mar;41(1-2):21-4. doi: 10.1007/BF01986388. PMID: 7521568. 9: Tabuchi Y, Kawarabayashi K, Komada T, Furuhama K. Protective effect of DS-4574 on gastric mucosal injury induced by acidified ethanol in rats. Eur J Pharmacol. 1993 Nov 30;250(1):197-9. doi: 10.1016/0014-2999(93)90644-w. PMID: 7907021. 10: Tabuchi Y, Furuhama K. Protective effect of DS-4574, a peptidoleukotriene receptor antagonist, against endotoxin-induced intestinal injury in rats. Eur J Pharmacol. 1995 Feb 6;273(3):281-4. doi: 10.1016/0014-2999(94)00739-t. PMID: 7737335. 11: Aibara S, Mori M, Tsubokawa M, Iwamoto T, Tsukada W. Antiallergic activity of 6-(2-cyclohexylethyl)-[1,3,4]thiadiazolo- [3,2-a]-1,2,3-triazolo-[4,5-d]pyrimidin-9(3H)-one (DS-4574) in rats. Int Arch Allergy Immunol. 1992;98(2):146-52. doi: 10.1159/000236178. PMID: 1379506. 12: Murayama N, Nakaoka M, Nomura H, Hakusui H. Radioimmunoassay for DS-4574, an anti-allergic agent: development, evaluation and application to human plasma samples. J Pharm Biomed Anal. 1995 Apr;13(4-5):671-3. doi: 10.1016/0731-7085(95)01302-2. PMID: 9696586. 13: Yokohama S, Miwa T, Aibara S, Fujiwara H, Matsumoto H, Nakayama K, Iwamoto T, Mori M, Moroi R, Tsukada W, et al. Synthesis and antiallergy activity of [1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one derivatives. II. 6-Alkyl- and 6-cycloalkylalkyl derivatives. Chem Pharm Bull (Tokyo). 1992 Sep;40(9):2391-8. doi: 10.1248/cpb.40.2391. PMID: 1446361.

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