MedKoo Cat#: 127008 | Name: JAK-IN-21
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

JAK-IN-21 (Example 4) is a selective and potent JAK inhibitor.

Chemical Structure

JAK-IN-21
JAK-IN-21
CAS#2445499-20-5

Theoretical Analysis

MedKoo Cat#: 127008

Name: JAK-IN-21

CAS#: 2445499-20-5

Chemical Formula: C19H16N8O

Exact Mass: 372.1447

Molecular Weight: 372.39

Elemental Analysis: C, 61.28; H, 4.33; N, 30.09; O, 4.30

Price and Availability

Size Price Availability Quantity
100mg USD 1,250.00 2 Weeks
500mg USD 3,650.00 2 Weeks
1g USD 5,250.00 2 Weeks
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Related CAS #
No Data
Synonym
JAK-IN-21; JAK IN-21; JAK-IN 21
IUPAC/Chemical Name
N-(cyanomethyl)-4-(2-((1-(cyanomethyl)-1H-pyrazol-4-yl)amino)-5-methylpyrimidin-4-yl)benzamide
InChi Key
HTJNRNRPDXBRQY-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H16N8O/c1-13-10-23-19(25-16-11-24-27(12-16)9-7-21)26-17(13)14-2-4-15(5-3-14)18(28)22-8-6-20/h2-5,10-12H,8-9H2,1H3,(H,22,28)(H,23,25,26)
SMILES Code
N#CCNC(C1=CC=C(C2=NC(NC3=CN(CC#N)N=C3)=NC=C2C)C=C1)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
JAK inhibitor
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 372.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Zhaokui WAN, et al. Benzamides of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof. Patent WO2020119819.