LLC-355 is an Autophagy-Tethering Compound for the Degradation of Discoidin Domain Receptor 1. LLC355 efficiently degraded DDR1 protein with a DC50 value of 150.8 nM in non-small cell lung cancer NCI-H23 cells. Mechanistic studies revealed LLC355 to induce DDR1 degradation via lysosome-mediated autophagy. LLC355 potently suppressed cancer cell tumorigenicity, migration, and invasion
MedKoo Cat#: 126973
Name: LLC-355
CAS#: N/A
Chemical Formula: C63H64ClF3N10O5
Exact Mass: 1132.4702
Molecular Weight: 1133.72
Elemental Analysis: C, 66.74; H, 5.69; Cl, 3.13; F, 5.03; N, 12.35; O, 7.06
The following data is based on the product molecular weight 1,133.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
