TCMDC-137332 | antimalarial | Plasmodium falciparum | CAS#165119-08-4

MedKoo Cat#: 126968 | Name: TCMDC-137332

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TCMDC-137332 is a compound that exhibits antimalarial activity against Plasmodium falciparum with an IC50 value of 7 nM.

Chemical Structure

TCMDC-137332

CAS#165119-08-4

Theoretical Analysis

MedKoo Cat#: 126968

Name: TCMDC-137332

CAS#: 165119-08-4

Chemical Formula: C17H18ClNO2

Exact Mass: 303.1026

Molecular Weight: 303.79

Elemental Analysis: C, 67.21; H, 5.97; Cl, 11.67; N, 4.61; O, 10.53

Price and Availability

Size	Price	Availability
50mg	USD 550.00	2 Weeks
100mg	USD 950.00	2 Weeks
200mg	USD 1,450.00	2 Weeks
500mg	USD 2,650.00	2 Weeks
1g	USD 3,650.00	2 Weeks
2g	USD 5,950.00	2 Weeks

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Related CAS #

No Data

Synonym

TCMDC-137332; TCMDC137332; TCMDC 137332

IUPAC/Chemical Name

N-(2-(4-chlorophenoxy)phenyl)pivalamide

InChi Key

CLAKLBXBJFDOMB-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H18ClNO2/c1-17(2,3)16(20)19-14-6-4-5-7-15(14)21-13-10-8-12(18)9-11-13/h4-11H,1-3H3,(H,19,20)

SMILES Code

CC(C)(C(NC1=CC=CC=C1OC2=CC=C(Cl)C=C2)=O)C

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Biological target:

In vitro activity:

The findings of an in vitro screening could not confirm the presumed nanomolar antiplasmodial activity of TCMDC-137332 and its derivatives. Reference: Weidner T, Nasereddin A, Preu L, Grünefeld J, Dzikowski R, Kunick C. Novel 2-Phenoxyanilide Congeners Derived from a Hit Structure of the TCAMS: Synthesis and Evaluation of Their in Vitro Activity against Plasmodium falciparum. Molecules. 2016 Feb 17;21(2):223. doi: 10.3390/molecules21020223. PMID: 26901174; PMCID: PMC6272959.

In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 303.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Weidner T, Nasereddin A, Preu L, Grünefeld J, Dzikowski R, Kunick C. Novel 2-Phenoxyanilide Congeners Derived from a Hit Structure of the TCAMS: Synthesis and Evaluation of Their in Vitro Activity against Plasmodium falciparum. Molecules. 2016 Feb 17;21(2):223. doi: 10.3390/molecules21020223. PMID: 26901174; PMCID: PMC6272959.