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MedKoo Cat#: 126908 | Name: JTT-551

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JTT-551 is a PTP1B inhibitor.

Chemical Structure

JTT-551
JTT-551
CAS#776309-04-7

Theoretical Analysis

MedKoo Cat#: 126908

Name: JTT-551

CAS#: 776309-04-7

Chemical Formula: C34H43N3O3S2

Exact Mass: 605.2746

Molecular Weight: 605.86

Elemental Analysis: C, 67.40; H, 7.15; N, 6.94; O, 7.92; S, 10.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
JTT-551; JTT551; JTT 551
IUPAC/Chemical Name
N-((5-(tert-butyl)thiazol-2-yl)methyl)-N-((4-(4-((4-(heptan-4-yl)phenoxy)methyl)phenyl)thiazol-2-yl)methyl)glycine
InChi Key
FKGBFRNVTCFMGU-UHFFFAOYSA-N
InChi Code
InChI=1S/C34H43N3O3S2/c1-6-8-25(9-7-2)26-14-16-28(17-15-26)40-22-24-10-12-27(13-11-24)29-23-41-32(36-29)20-37(21-33(38)39)19-31-35-18-30(42-31)34(3,4)5/h10-18,23,25H,6-9,19-22H2,1-5H3,(H,38,39)
SMILES Code
CCCC(CCC)C1=CC=C(C=C1)OCC2=CC=C(C=C2)C3=CSC(=N3)CN(CC4=NC=C(S4)C(C)(C)C)CC(=O)O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 605.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fukuda S, Ohta T, Sakata S, Morinaga H, Ito M, Nakagawa Y, Tanaka M, Matsushita M. Pharmacological profiles of a novel protein tyrosine phosphatase 1B inhibitor, JTT-551. Diabetes Obes Metab. 2010 Apr;12(4):299-306. doi: 10.1111/j.1463-1326.2009.01162.x. PMID: 20380650. 2: Ito M, Fukuda S, Sakata S, Morinaga H, Ohta T. Pharmacological effects of JTT-551, a novel protein tyrosine phosphatase 1B inhibitor, in diet-induced obesity mice. J Diabetes Res. 2014;2014:680348. doi: 10.1155/2014/680348. Epub 2014 May 29. PMID: 24987707; PMCID: PMC4060493. 3: Liu Z, Gao H, Zhao Z, Huang M, Wang S, Zhan J. Status of research on natural protein tyrosine phosphatase 1B inhibitors as potential antidiabetic agents: Update. Biomed Pharmacother. 2023 Jan;157:113990. doi: 10.1016/j.biopha.2022.113990. Epub 2022 Nov 29. PMID: 36459712. 4: Singh S, Singh Grewal A, Grover R, Sharma N, Chopra B, Kumar Dhingra A, Arora S, Redhu S, Lather V. Recent updates on development of protein-tyrosine phosphatase 1B inhibitors for treatment of diabetes, obesity and related disorders. Bioorg Chem. 2022 Apr;121:105626. doi: 10.1016/j.bioorg.2022.105626. Epub 2022 Feb 24. PMID: 35255350.