BIO-8169 is a potent, selective, and brain-penetrant imidazopyrimidine series of IRAK4 inhibitor (IC50 = 0.2 nM). BIO-8169 reduced the in vivo production of pro-inflammatory cytokines, was well tolerated in safety studies in rodents and dog at margins well above the predicted efficacious exposure and showed promising results in a mouse model for multiple sclerosis.
MedKoo Cat#: 126907
Name: BIO-8169
CAS#: N/A
Chemical Formula: C24H27N5O4
Exact Mass: 449.2063
Molecular Weight: 449.51
Elemental Analysis: C, 64.13; H, 6.05; N, 15.58; O, 14.24
The following data is based on the product molecular weight 449.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
