XYD190 is a highly potent and efficient CBP/p300 degrader with strong in vivo antitumor activity. XYD190 potently inhibited the growth of AML cells with low nanomolar IC50 values and effectively degraded CBP and p300 proteins in a concentration- and time-dependent manner. Mechanistic studies confirmed that XYD190 can selectively bind to CBP/p300 bromodomains and induce CBP and p300 degradation in bromodomain family proteins in a CRBN- and proteasome-dependent manner.
MedKoo Cat#: 126853
Name: XYD190
CAS#: N/A
Chemical Formula: C55H50F2N10O7
Exact Mass: 1000.3832
Molecular Weight: 1001.06
Elemental Analysis: C, 65.99; H, 5.03; F, 3.80; N, 13.99; O, 11.19
The following data is based on the product molecular weight 1,001.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
