MedKoo Cat#: 126770 | Name: UNC7700

Description:

WARNING: This product is for research use only, not for human or veterinary use.

UNC7700 is an EED-binding PROTAC degrader with DC50 (EED) = 110 nM, and DC50 (EZH2) = 280 nM.

Chemical Structure

UNC7700
UNC7700
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 126770

Name: UNC7700

CAS#: N/A

Chemical Formula: C44H48N10O6S

Exact Mass: 844.3479

Molecular Weight: 844.99

Elemental Analysis: C, 62.54; H, 5.73; N, 16.58; O, 11.36; S, 3.79

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
UNC7700; UNC-7700; UNC 7700
IUPAC/Chemical Name
(2S,4R)-1-((S)-2-((1s,3R)-3-(4-(5-((furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)benzamido)cyclobutane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
InChi Key
ARONHQOAKYUHEE-AOBTXCIISA-N
InChi Code
InChI=1S/C44H48N10O6S/c1-25-36(61-24-48-25)28-9-7-26(8-10-28)19-45-41(58)35-18-32(55)22-53(35)42(59)37(44(2,3)4)51-40(57)30-16-31(17-30)50-39(56)29-13-11-27(12-14-29)34-21-47-43(54-23-49-52-38(34)54)46-20-33-6-5-15-60-33/h5-15,21,23-24,30-32,35,37,55H,16-20,22H2,1-4H3,(H,45,58)(H,46,47)(H,50,56)(H,51,57)/t30-,31+,32-,35+,37-/m1/s1
SMILES Code
O=C(N[C@H]1C[C@@H](C(N[C@@H](C(C)(C)C)C(N2C[C@H](O)C[C@H]2C(NCC3=CC=C(C4=C(C)N=CS4)C=C3)=O)=O)=O)C1)C5=CC=C(C6=CN=C(NCC7=CC=CO7)N8C6=NN=C8)C=C5
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 844.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Bashore FM, Foley CA, Ong HW, Rectenwald JM, Hanley RP, Norris-Drouin JL, Cholensky SH, Mills CA, Pearce KH, Herring LE, Kireev D, Frye SV, James LI. PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components. ACS Chem Biol. 2023 Mar 17;18(3):494-507. doi: 10.1021/acschembio.2c00804. Epub 2023 Mar 6. PMID: 36877831; PMCID: PMC10023369.