AZD0780, also known as EX-A6975, is a PCSK9 Inhibitor. AZD-0780 exhibits bind affinity for PCSK9 ( Kd <200 nM). AZD0780's bioactivity centers on reducing low-density lipoprotein cholesterol (LDL-C) levels in plasma. AZD-0780 stabilizes this protein, preventing it from degrading LDL receptors, which enhances LDL-C clearance from the bloodstream. AZD-0780 demonstrated a statistically significant 52% reduction in LDL-C levels when administered with rosuvastatin, achieving a total 78% reduction from baseline in treatment-naive participants with hypercholesterolemia. AZD-0780 is a potential next-generation treatment for patients unable to manage LDL-C with statins alone.
MedKoo Cat#: 556369
Name: AZD-0780
CAS#: 2455427-91-3
Chemical Formula: C20H20F2N6O2
Exact Mass: 414.1616
Molecular Weight: 414.42
Elemental Analysis: C, 57.97; H, 4.86; F, 9.17; N, 20.28; O, 7.72
The following data is based on the product molecular weight 414.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
