MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 408200 | Name: CP-10
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CP-10 is a PROTAC degrade with highly selective, specific, and remarkable CDK6 degradation (DC50=2.1 nM). CP-10 induced nearly 72% degradation of CDK6 at l0 nM and 89% at 100 nM inhuman glioblastoma U251 cells (Fig. 3C). The degradation of CDK4 induced by CP-10 was far weaker than that of CDK6 (DC50 50~80 fold), albeit similar palbociclib affinity and sequence homology of these two kinases.

Chemical Structure

CP-10
CP-10
CAS#2366268-80-4

Theoretical Analysis

MedKoo Cat#: 408200

Name: CP-10

CAS#: 2366268-80-4

Chemical Formula: C44H49N13O7

Exact Mass: 871.3878

Molecular Weight: 871.96

Elemental Analysis: C, 60.61; H, 5.66; N, 20.88; O, 12.84

Price and Availability

Size Price Availability Quantity
5mg USD 1,250.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
CP-10; CP 10; CP10;
IUPAC/Chemical Name
4-((2-(2-(4-((4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
InChi Key
PACRWHUPEPCFHX-UHFFFAOYSA-N
InChi Code
InChI=1S/C44H49N13O7/c1-26-32-23-47-44(50-39(32)56(29-6-3-4-7-29)42(62)37(26)27(2)58)48-35-12-10-30(22-46-35)54-17-15-53(16-18-54)24-28-25-55(52-51-28)19-21-64-20-14-45-33-9-5-8-31-38(33)43(63)57(41(31)61)34-11-13-36(59)49-40(34)60/h5,8-10,12,22-23,25,29,34,45H,3-4,6-7,11,13-21,24H2,1-2H3,(H,49,59,60)(H,46,47,48,50)
SMILES Code
CC(C(C1=O)=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCOCCNC6=CC=CC(C(N7C8CCC(NC8=O)=O)=O)=C6C7=O)N=N5)CC4)C=N3)N=C2N1C9CCCC9)=O
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 871.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hu SP, Harrison C, Xu K, Cornish CJ, Geczy CL. Induction of the chemotactic S100 protein, CP-10, in monocyte/macrophages by lipopolysaccharide. Blood. 1996 May 1;87(9):3919-28. PMID: 8611721. 2: Cornish CJ, Devery JM, Poronnik P, Lackmann M, Cook DI, Geczy CL. S100 protein CP-10 stimulates myeloid cell chemotaxis without activation. J Cell Physiol. 1996 Feb;166(2):427-37. doi: 10.1002/(SICI)1097-4652(199602)166:2<427::AID-JCP21>3.0.CO;2-6. PMID: 8592003. 3: Iismaa SE, Hu S, Kocher M, Lackmann M, Harrison CA, Thliveris S, Geczy CL. Recombinant and cellular expression of the murine chemotactic protein, CP-10. DNA Cell Biol. 1994 Feb;13(2):183-92. doi: 10.1089/dna.1994.13.183. PMID: 8179823. 4: Kocher M, Kenny PA, Farram E, Abdul Majid KB, Finlay-Jones JJ, Geczy C L. Functional chemotactic factor CP-10 and MRP-14 are abundant in murine abscesses. Infect Immun. 1996 Apr;64(4):1342-50. doi: 10.1128/iai.64.4.1342-1350.1996. PMID: 8606099; PMCID: PMC173924. 5: Kumar RK, Harrison CA, Cornish CJ, Kocher M, Geczy CL. Immunodetection of the murine chemotactic protein CP-10 in bleomycin-induced pulmonary injury. Pathology. 1998 Feb;30(1):51-6. doi: 10.1080/00313029800169665. PMID: 9534208. 6: Yen T, Harrison CA, Devery JM, Leong S, Iismaa SE, Yoshimura T, Geczy CL. Induction of the S100 chemotactic protein, CP-10, in murine microvascular endothelial cells by proinflammatory stimuli. Blood. 1997 Dec 15;90(12):4812-21. PMID: 9389698. 7: Lazoura E, McLeish MJ, Aguilar MI. Studies on the conformational properties of CP-10(42-55), the hinge region of CP-10, using circular dichroism and RP- HPLC. J Pept Res. 2000 Jun;55(6):411-8. doi: 10.1034/j.1399-3011.2000.00690.x. PMID: 10888197. 8: Devery JM, King NJ, Geczy CL. Acute inflammatory activity of the S100 protein CP-10. Activation of neutrophils in vivo and in vitro. J Immunol. 1994 Feb 15;152(4):1888-97. PMID: 8120396. 9: Deininger MH, Zhao Y, Schluesener HJ. CP-10, a chemotactic peptide, is expressed in lesions of experimental autoimmune encephalomyelitis, neuritis, uveitis and in C6 gliomas. J Neuroimmunol. 1999 Jan 1;93(1-2):156-63. doi: 10.1016/s0165-5728(98)00221-5. PMID: 10378879. 10: Lackmann M, Rajasekariah P, Iismaa SE, Jones G, Cornish CJ, Hu S, Simpson RJ, Moritz RL, Geczy CL. Identification of a chemotactic domain of the pro- inflammatory S100 protein CP-10. J Immunol. 1993 Apr 1;150(7):2981-91. PMID: 8454868. 11: Lackmann M, Cornish CJ, Simpson RJ, Moritz RL, Geczy CL. Purification and structural analysis of a murine chemotactic cytokine (CP-10) with sequence homology to S100 proteins. J Biol Chem. 1992 Apr 15;267(11):7499-504. PMID: 1559987. 12: Nagai K, Saruki K, Kako M. [Serodiagnosis of HCV infection by means of HCV core antibodies (CP-9 Ab, CP-10 Ab)]. Nihon Rinsho. 1995 Sep;53 Suppl(Pt 1):224-9. Japanese. PMID: 7563705. 13: Geczy C. Regulation and proinflammatory properties of the chemotactic protein, CP-10. Biochim Biophys Acta. 1996 Oct 11;1313(3):246-52. doi: 10.1016/0167-4889(96)00096-1. PMID: 8898861. 14: Song X, Heimburg-Molinaro J, Smith DF, Cummings RD. Derivatization of free natural glycans for incorporation onto glycan arrays: derivatizing glycans on the microscale for microarray and other applications (ms# CP-10-0194). Curr Protoc Chem Biol. 2011 Apr 1;3(2):53-63. doi: 10.1002/9780470559277.ch100194. PMID: 22022660; PMCID: PMC3196601.